methyl (phenyl 5-tert-butoxycarbonylamino-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-2-nonulopyranosid)uronate | 1046456-64-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl (phenyl 5-tert-butoxycarbonylamino-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-2-nonulopyranosid)uronate
• CAS: 1046456-64-7
• 化学式: C₂₁H₃₁NO₉S
• 分子量: 473.544
• InChiKey: HKMHOJLZGSBONX-GVXYBPPOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.41
• 重原子数：
  32.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  154.78
• 氢给体数：
  5.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  methyl (phenyl 5-tert-butoxycarbonylamino-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-2-nonulopyranosid)uronate 在 lithium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 以35 mg的产率得到thiophenyl 5-N-tert-butoxycarbonyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid
  参考文献：
  名称：

  Design, Synthesis, and Evaluation of N-Acyl Modified Sialic Acids as Inhibitors of Adenoviruses Causing Epidemic Keratoconjunctivitis

  摘要：

  The adenovirus serotype Ad37 binds to and infects human corneal epithelial (HCE) cells through attachment to cellular glycoproteins carrying terminal sialic acids. By use of the crystallographic structure of the sialic acid-interacting domain of the Ad37 fiber protein in complex with sialyllactose, a set of N-acyl modified sialic acids were designed to improve binding affinity through increased hydrophobic interactions. These N-acyl modified sialic acids and their corresponding multivalent human serum albumin (HSA) conjugates were synthesized and tested in Ad37 cell binding and cell infectivity assays. Compounds bearing small substituents were as effective inhibitors as sialic acid. X-ray crystallography and overlays with the Ad37-sialyllactose complex showed that the N-acyl modified sialic acids were positioned in the same orientation as sialic acid. Their multivalent counterparts achieved a strong multivalency effect and were more effective to prevent infection than the monomers. Unfortunately, they were less active as inhibitors than multivalent sialic acid.

  DOI：

  10.1021/jm801609s
• 作为产物：
  描述：

  (1S,2R)-1-((2R,3R,4S,6S)-4-acetoxy-3-((tert-butoxycarbonyl)amino)-6-(methoxycarbonyl)-6-(phenylthio)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl triacetate 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 11.0h， 生成 methyl (phenyl 5-tert-butoxycarbonylamino-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-2-nonulopyranosid)uronate
  参考文献：
  名称：

  Sialylation reactions with 5-N,7-O-carbonyl-protected sialyl donors: unusual stereoselectivity with nitrile solvent assistance

  摘要：

  A 5-N,7-O-carbonyl-protected sialyl donor was synthesized, and, unexpectedly, this donor showed beta-selectivity (alpha/beta = 1/2.4-1/20) on coupling with sugar acceptors in acetonitrile upon treatment with various promoter systems. For the coupling reaction in dichloromethane, a modified Ellervik's method (IBr and AgClO4 center dot H2O) was highly effective in activating the 5-N,7-O-carbonyl donor, providing moderate alpha-selectivity (alpha/beta = similar to 1.8/1). (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2008.05.005