托马酸格隆 | 1624259-25-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 托马酸格隆
• 英文名称: Glycopyrronium tosilate hydrate
• 英文别名: (1,1-dimethylpyrrolidin-1-ium-3-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate;4-methylbenzenesulfonate;hydrate
• CAS: 1624259-25-1
• 化学式: C26H37NO7S
• 分子量: 507.6
• InChiKey: UOWOLENSDISMPG-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.53
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• PROCESS FOR PRODUCTION OF GLYCOPYRRONIUM TOSYLATE
  申请人：Dermira, Inc.

  公开号：US20160052879A1

  公开（公告）日：2016-02-25

  Provided herein are methods for the production of glycopyrronium tosylate and glycopyrronium tosylate compositions. Also provided herein are compositions useful in the production of glycopyrronium tosylate. Additionally provided herein are glycopyrronium tosylate compositions. Glycopyrronium tosylate is useful for the treatment of, among other conditions, hyperhidrosis.

  本文提供了生产甘哌铵对甲苯磺酸盐和甘哌铵对甲苯磺酸盐组合物的方法。本文还提供了在生产甘哌铵对甲苯磺酸盐时有用的组合物。此外，本文还提供了甘哌铵对甲苯磺酸盐组合物。甘哌铵对甲苯磺酸盐对于治疗多种疾病，包括多汗症等，具有一定的用途。
• [EN] GLYCOPYRROLATE SALTS<br/>[FR] SELS DE GLYCOPYRROLATE
  申请人：DERMIRA INC

  公开号：WO2014134510A1

  公开（公告）日：2014-09-04

  Salts of glycopyrrolate, including solid forms and formulations such as topicals thereof, are disclosed. Methods of making glycopyrrolate salts, including formulations such as topicals thereof, and methods of treating hyperhidrosis with salts of glycopyrrolate, and formulations such as topicals thereof, are disclosed.

  本发明揭示了格隆溴铵的盐，包括固体形式和其局部制剂。揭示了制备格隆溴铵盐的方法，包括其局部制剂，并且揭示了使用格隆溴铵盐及其局部制剂治疗多汗症的方法。
• Glycopyrrolate Salts
  申请人：DERMIRA, INC.

  公开号：US20140371290A1

  公开（公告）日：2014-12-18

  Salts of glycopyrrolate, including solid forms and formulations such as topicals thereof, are disclosed. Methods of making glycopyrrolate salts, including formulations such as topicals thereof, and methods of treating hyperhidrosis with salts of glycopyrrolate, and formulations such as topicals thereof, are disclosed.

  本文披露了格隆溴铵的盐，包括固体形式和其局部制剂。同时，还披露了制备格隆溴铵盐及其制剂，以及利用格隆溴铵盐及其制剂治疗多汗症的方法。
• METHOD OF MAKING THREO GLYCOPYRROLATE TOSYLATE
  申请人：Dermira, Inc.

  公开号：EP3842419A1

  公开（公告）日：2021-06-30

  Salts of glycopyrrolate, including solid forms and formulations such as topicals thereof, are disclosed. Methods of making glycopyrrolate salts, including formulations such as topicals thereof, and methods of treating hyperhidrosis with salts of glycopyrrolate, and formulations such as topicals thereof, are disclosed.

  本发明公开了甘草酸盐，包括固体形式和制剂，如外用药。公开了甘草酸盐的制造方法，包括其制剂如外用药，以及用甘草酸盐和其制剂如外用药治疗多汗症的方法。
• Glycopyrrolate salts
  申请人：Dermira, Inc.

  公开号：US10004717B2

  公开（公告）日：2018-06-26

  Salts of glycopyrrolate, including solid forms and formulations such as topicals thereof, are disclosed. Methods of making glycopyrrolate salts, including formulations such as topicals thereof, and methods of treating hyperhidrosis with salts of glycopyrrolate, and formulations such as topicals thereof, are disclosed.

  本发明公开了甘草酸盐，包括固体形式和制剂，如外用药。公开了甘草酸盐的制造方法，包括其制剂如外用药，以及用甘草酸盐和其制剂如外用药治疗多汗症的方法。