3-phenyl-3-(trimethylsilyloxy)butanoic acid ethyl ester | 73250-19-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-phenyl-3-(trimethylsilyloxy)butanoic acid ethyl ester
• 英文别名: ethyl 3-phenyl-3-trimethylsiloxybutanoate；Ethyl 3-phenyl-3-trimethylsilyloxybutanoate
• CAS: 73250-19-8
• 化学式: C₁₅H₂₄O₃Si
• 分子量: 280.439
• InChiKey: DDFUSWLQMUUVOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.71
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  [(1-乙氧基乙烯基)氧基]三甲基硅烷 、 苯乙酮 以 甲苯 为溶剂， 反应 6.0h， 以87%的产率得到3-phenyl-3-(trimethylsilyloxy)butanoic acid ethyl ester
  参考文献：
  名称：

  The Mukaiyama Aldol and Mukaiyama–Michael Reactions Promoted by Commercially Available Molecular Sieves

  摘要：

  The Mukaiyama aldol reaction of silyl ketene acetals with aldehydes has been effected by using commercially available 4 angstrom molecular sieves (4 angstrom MS) as a promoter. Various silyl ketene acetals and silyl enol ethers have been shown to be effective nucleophiles for this reaction. For the first time, it has been found that 4 angstrom MS can promote the Mukaiyama Michael addition reactions of silyl ketene acetals to alpha,beta-enones.

  DOI：

  10.3987/com-09-s(s)133

文献信息

• Phosphazene base-catalyzed condensation of trimethylsilylacetate with carbonyl compounds
  作者：Koji Kobayashi、Masahiro Ueno、Yoshinori Kondo

  DOI：10.1039/b606056k

  日期：——

  The t-Bu-P4 base was found to be an excellent catalyst for the condensation of trimethylsilylacetate or trimethylacetonitrile with carbonyl compounds to form functionalized alkenes and beta-enaminoesters were also synthesized by the condensation with formanilides.

  发现t-Bu-P4碱是乙酸三甲基甲硅烷基酯或三甲基乙腈与羰基化合物缩合以形成官能化烯烃的极佳催化剂，并且通过与甲酰苯胺的缩合反应也合成了β-烯氨基酯。
• AYI A. I.; CONDOM R.; WADE T. N.; GUEDJ R., J. FLUOR. CHEM., 1979, 14, NO 6, 437-454
  作者：AYI A. I.、 CONDOM R.、 WADE T. N.、 GUEDJ R.

  DOI：——

  日期：——
• BURKHARDT, ELIZABETH R.;DONEY, JEFFREY J.;SLOUGH, GREG A.;STACK, JEFFREY +, PURE AND APPL. CHEM., 60,(1988) N 1, 1-6
  作者：BURKHARDT, ELIZABETH R.、DONEY, JEFFREY J.、SLOUGH, GREG A.、STACK, JEFFREY +

  DOI：——

  日期：——