N-(3-bromo-4-chlorophenyl)-3-chloropropanamide | 22444-07-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-bromo-4-chlorophenyl)-3-chloropropanamide
• 英文别名: N-(3-Bromo-4-chloro-phenyl)-3-chloro-propionamide
• CAS: 22444-07-1
• 化学式: C₉H₈BrCl₂NO
• 分子量: 296.979
• InChiKey: YQQIGFQNEAJXFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(3-bromo-4-chlorophenyl)-3-chloropropanamide 在 aluminum (III) chloride 作用下， 生成 5-bromo-6-chloro-3,4-dihydroquinolin-2(1H)-one
  参考文献：
  名称：

  [EN] BCL-XL INHIBITORS
  [FR] INHIBITEURS DE BCL-XL

  摘要：

  Disclosed herein is a compound of Formula (I) for inhibiting Bcl-xL and treating a disease associated with the undesirable Bcl-xL activity (Bcl-xL related diseases), a method of using the compounds disclosed herein for treating tumor or cancer, and a pharmaceutical composition comprising the same.

  公开号：

  WO2023185986A1

文献信息

• ARYL-SUBSTITUTED DIHYDROQUINOLINONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
  申请人：Neomed Institute

  公开号：EP3334717B1

  公开（公告）日：2020-07-01
• [EN] ARYL-SUBSTITUTED DIHYDROQUINOLINONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS<br/>[FR] DIHYDROQUINOLINONES SUBSTITUÉES PAR UN GROUPE ARYLE, LEUR PRÉPARATION ET LEUR UTILISATION COMME AGENTS PHARMACEUTIQUES
  申请人：NEOMED INST

  公开号：WO2017024408A1

  公开（公告）日：2017-02-16

  This application relates to aryl-substituted dihydroquinolinones of formula (I), compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to aryl-substituted dihydroquinolinones and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.