1,20-(icosanedioxy)bis-(3'-phosphatidyl-2'-deoxythymidine) | 445467-44-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核糖核苷3'-磷酸盐
• 英文名称: 1,20-(icosanedioxy)bis-(3'-phosphatidyl-2'-deoxythymidine)
• 英文别名: 20-[hydroxy-[(2R,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxyphosphoryl]oxyicosyl [(2R,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] hydrogen phosphate
• CAS: 445467-44-7
• 化学式: C₄₀H₆₈N₄O₁₆P₂
• 分子量: 922.945
• InChiKey: QXYGSRIJJSWTJF-UWNKZCSISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  62
• 可旋转键数：
  31
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  269
• 氢给体数：
  6
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  1,20-(icosanedioxy)bis-(3'-phosphatidyl-2'-deoxythymidine) 以 水 为溶剂， 生成
  参考文献：
  名称：

  可自组装的纳米纤维中的1，omega-胸苷酸附加的保卫两性的螺旋度的可逆光化学转化。

  摘要：

  DOI：

  10.1002/anie.200601173
• 作为产物：
  描述：

  以 水 为溶剂， 生成 1,20-(icosanedioxy)bis-(3'-phosphatidyl-2'-deoxythymidine)
  参考文献：
  名称：

  可自组装的纳米纤维中的1，omega-胸苷酸附加的保卫两性的螺旋度的可逆光化学转化。

  摘要：

  DOI：

  10.1002/anie.200601173

文献信息

• Nucleolipids as Potential Organogelators
  作者：Helmut Rosemeyer、Eva-Maria Stürenberg、Piet Herdewijn

  DOI：10.1080/15257770701508521

  日期：2007.11.26

  Four different series of nucleolipids or bola-nuclcolipids were synthesized or re-synthesized. Most of the compounds were studied with respect to their gelation properties toward either water or aromatic, hetero-aromatic, and aliphatic hydrocarbons. Bola-nucteolipids 6 and 7 do not gelate any solvent tested, neither as sole additive nor by adding up to 10 wt % of a 1:1 mixture. The nucleolipid 22 carrying the antiviral acyclovir as a head group proved to be a potent organogelator for aromatic hydrocarbons such as toluene, but not for hetarenes, aliphatic hydrocarbons or water. The mono-tailed nucleolipid 24 exhibits excellent organogelator Properties for both aromatic and aliphatic hydrocarbons. These were studied as a function of concentration and temperature.