(S)-1-(2-Fluorophenyl)propan-1-amine | 1075715-56-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-1-(2-Fluorophenyl)propan-1-amine
• 英文别名: (1S)-1-(2-fluorophenyl)propan-1-amine
• CAS: 1075715-56-8
• 化学式: C₉H₁₂FN
• 分子量: 153.2
• InChiKey: CQTLDYYIWIOAAV-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Pyridone derivatives as NK3 antagonists
  申请人：Khanzhin Nikolay

  公开号：US20110144164A1

  公开（公告）日：2011-06-16

  The present invention relates to compounds useful in therapy, in particular in the treatment of psychosis, to compositions comprising said compounds, and to methods of treating diseases comprising the administration of said compounds.

  本发明涉及在治疗中有用的化合物，特别是在治疗精神病方面，涉及包含该化合物的组合物，以及包括给予该化合物的治疗方法。
• [EN] PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS<br/>[FR] DÉRIVÉS DE PYRIDONE ANTAGONISTES DE NK3
  申请人：LUNDBECK & CO AS H

  公开号：WO2011072691A1

  公开（公告）日：2011-06-23

  The present invention relates to compound of formula (I) useful in therapy, in particular in the treatment of psychosis, to compositions comprising said compounds, and to methods of treating diseases comprising the administration of said compounds.

  本发明涉及一种具有式（I）的化合物，用于治疗，特别是在治疗精神病方面，包括所述化合物的组合物，以及通过给予该化合物来治疗疾病的方法。
• ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS
  申请人：Simonsen Klaus Baek

  公开号：US20090143402A1

  公开（公告）日：2009-06-04

  Isoquinolone derivatives of the general formula are provided. The compounds are NK3 antagonists and useful for the treatment of e.g. psychosis and schizophrenia.

  提供了一般化合物的异喹啉衍生物。这些化合物是NK3拮抗剂，可用于治疗精神病和精神分裂症等疾病。
• Optically active 1-(fluoro-, trifluoromethyl-or trifluoromethoxy-substituted phenyl) alkylamine n-monoalkyl derivatives and process for producing same
  申请人：——

  公开号：US20040235961A1

  公开（公告）日：2004-11-25

  An optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative represented by the formula 4 is produced by a process including (a) reacting an optically active secondary amine, represented by the formula 1, with an alkylation agent R 2 —X, in the presence of a base, thereby converting the secondary amine into an optically active tertiary amine represented by the formula 3; and (b) subjecting the tertiary amine to a hydrogenolysis, thereby producing the N-monoalkyl derivative, 1 wherein R represents a fluorine atom, trifluoromethyl group or trifluoromethoxy group, n represents an integer of from 1 to 5, each of R 1 and R 2 independently represents an alkyl group having a carbon atom number of from 1 to 6, Me represents a methyl group, Ar represents a phenyl group or 1- or 2-naphthyl group, * represents a chiral carbon, and X represents a leaving group.

  以式 4 为代表的光学活性 1-(氟、三氟甲基或三氟甲氧基取代苯基)烷基胺 N-单 烷基衍生物的制备方法包括 (a) 式 1 所代表的光学活性仲胺与烷基化剂 R 2 -X，在碱存在下反应，从而将仲胺转化为由式 3 表示的光学活性叔胺；以及 (b) 将叔胺进行氢解，从而生成 N-单烷基衍生物、 1 其中 R 代表氟原子、三氟甲基或三氟甲氧基，n 代表 1 至 5 的整数，每个 R 1 和 R 2 分别代表碳原子数为 1 至 6 的烷基，Me 代表甲基，Ar 代表苯基或 1 或 2-萘基，* 代表手性碳，X 代表离去基团。
• METHOD FOR PRODUCING OPTICALLY ACTIVE 1-(FLUORO-, TRIFLUOROMETHYL- OR TRIFLUOROMETHOXY-SUBSTITUTED PHENYL)ALKYLAMINE N-MONOALKYL DERIVATIVE
  申请人：Central Glass Co., Ltd.

  公开号：EP2036881B1

  公开（公告）日：2013-09-25