(2R)-3-(4'-dibenzofuran-4-yl-biphenyl-4-ylmethylsulfanyl)-2-(3,3-dimethylbutyryl-amino)-propionic acid | 796071-42-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R)-3-(4'-dibenzofuran-4-yl-biphenyl-4-ylmethylsulfanyl)-2-(3,3-dimethylbutyryl-amino)-propionic acid
• 英文别名: (2R)-3-[[4-(4-dibenzofuran-4-ylphenyl)phenyl]methylsulfanyl]-2-(3,3-dimethylbutanoylamino)propanoic acid
• CAS: 796071-42-6
• 化学式: C₃₄H₃₃NO₄S
• 分子量: 551.706
• InChiKey: DCQDXWGPTHMLOH-LJAQVGFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Substituted amino carboxylic acids
  申请人：Whitehouse Darren

  公开号：US20060122223A1

  公开（公告）日：2006-06-08

  Disclosed are compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

  本发明揭示了公式（I）的化合物及其药学上可接受的盐，它们可用于治疗与胰岛素抵抗、瘦素抵抗或高血糖相关的代谢性疾病。本发明的化合物包括蛋白酪氨酸磷酸酶抑制剂，特别是蛋白酪氨酸磷酸酶-1B（PTP-1B），它们可用于治疗糖尿病和其他PTP介导的疾病，如癌症、神经退行性疾病等。本发明还揭示了包括本发明化合物的制药组合物以及使用这些化合物治疗上述疾病的方法。
• SUBSTITUTED AMINO ACIDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS
  申请人：The Institutes for Pharmaceutical Discovery, LLC

  公开号：EP1814869A2

  公开（公告）日：2007-08-08
• US7358248B2
  申请人：——

  公开号：US7358248B2

  公开（公告）日：2008-04-15
• US7498356B2
  申请人：——

  公开号：US7498356B2

  公开（公告）日：2009-03-03
• [EN] SUBSTITUTED AMINO CARBOXYLIC ACIDS<br/>[FR] ACIDES AMINO CARBOXYLIQUES SUBSTITUES
  申请人：INST FOR PHARM DISCOVERY INC

  公开号：WO2006055725A2

  公开（公告）日：2006-05-26

  [EN] Disclosed are compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
  [FR] L'invention concerne des composés et des sels pharmaceutiquement acceptables de la formule (I) lesquels sont utiles dans le traitement de troubles métaboliques associés à la résistance insulinique, la résistance à la leptine ou l'hyperglycémie. Les composés de l'invention comprennent des inhibiteurs de protéine tyrosine phosphatases, en particulier la protéine tyrosine phosphatase-1B (PTP-1B), qui sont utiles dans le traitement du diabète et d'autres maladies médiées par PTP telles que le cancer, les maladies neurodégénératives et analogues. L'invention concerne également des compositions pharmaceutiques contenant les composés de l'invention ainsi que des méthodes de traitement des états précités à l'aide de ces composés.