N,N'-bis(diphenylphosphino)-N,N'-bis(1-phenylethyl)ethylenediamine | 330854-08-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-bis(diphenylphosphino)-N,N'-bis(1-phenylethyl)ethylenediamine
• 英文别名: 1,2 bis-[N-(1-phenylethyl), N-(diphenylphosphino)amino] ethane；N,N'-bis(diphenylphosphanyl)-N,N'-bis(1-phenylethyl)ethane-1,2-diamine
• CAS: 330854-08-5
• 化学式: C₄₂H₄₂N₂P₂
• 分子量: 636.756
• InChiKey: TYRRWPJYBCYJPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.21
• 重原子数：
  46.0
• 可旋转键数：
  13.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  6.48
• 氢给体数：
  0.0
• 氢受体数：
  2.0

文献信息

• Axially Asymmetric Phosphorus Compound and Production Method Thereof
  申请人：Tanaka Ken

  公开号：US20090227805A1

  公开（公告）日：2009-09-10

  Problem to be Solved: To provide an axially asymmetric optically active biarylphosphorus compound that can easily produced without the step of optical resolution which was almost indispensable in conventional methods. Solution: A method for producing an axially asymmetric phosphorus compound represented by the general formula (1), comprising a cycloaddition reaction of a compound having a triple bond with the use of a catalyst containing rhodium metal and an optically active bisphosphine. (In the formula, J is an oxygen atom, a sulfur atom or BH 3 ; R 1 and R 2 independently are an alkyl, cycloalkyl, aryl, alkoxy and aryloxy group; a1 and a2 independently are 0 or 1; R 3 to R 10 independently are an alkyl, cycloalkyl, aryl, alkoxy and aryloxy group; two among R 3 to R 10 may form a ring; and * is axial asymmetry.)

  要解决的问题：提供一种轴向不对称的光学活性联苯磷化合物，可以在传统方法中几乎不可或缺的光学分辨步骤之外轻松生产。 解决方案：一种生产由通式（1）表示的轴向不对称磷化合物的方法，包括使用含有铑金属和光学活性双膦的催化剂进行含有三键化合物的环加成反应。 （在公式中，J是氧原子、硫原子或BH3；R1和R2独立地是烷基、环烷基、芳基、烷氧基和芳氧基；a1和a2独立地为0或1；R3到R10独立地是烷基、环烷基、芳基、烷氧基和芳氧基；R3到R10中的两个可能形成环；*表示轴向不对称。）
• Method of manufacturing cyano compounds
  申请人：Shibasaki Masakatsu

  公开号：US20050004388A1

  公开（公告）日：2005-01-06

  A method of manufacturing a cyano compound by reacting a carbonyl compound with a nitrile compound having at least one α-hydrogen atom in the presence of a ligand and a metal compound of formula (III), MX  (III) wherein M is a copper atom or a silver atom, and X is an alkoxy group, an alkyl group, an aryl group or an anionic residue.

  通过在配体和化合物的存在下，将羰基化合物与至少含有一个α-氢原子的腈化合物反应，制备氰基化合物的方法，其中化合物的公式为（III），MX，其中M是铜原子或银原子，X是烷氧基团、烷基团、芳基团或阴离子残基。
• Method of preparing 4-R-substituted 4-demethoxydaunorubicin
  申请人：——

  公开号：US20040236086A1

  公开（公告）日：2004-11-25

  A method of synthesizing 4-R-substituted anthracyclines and their corresponding salts from 4-demethyldaunorubicin includes the steps of treating 4-demethyldaunorubicin with a sulfonylating agent to form 4-demethyl-4-sulfonyl-R 3 -daunorubicin. 4-Demethyl-4-R 3 -sulfonyl-daunorubicin is then subject to a reducing agent in the presence of a transition metal catalyst in a temperature range of about 30° C. to about 100° C. in a polar aprotic solvent in an inert atmosphere. Protected 4-demethoxy-4-R-daunomycin then undergoes hydrolysis in a basic solution to form the 4-R-substituted anthracyclines. The novel method lacks the step of forming a stereospecific glycoside bond between aglycone and aminoglycoside. The method also increases the yield of the final product up to 30 to 40%.

  一种从4-去甲基多柔比星合成4-R-取代蒽环素及其相应盐的方法，包括以下步骤：用磺酰化试剂处理4-去甲基多柔比星，形成4-去甲基-4-磺酰基-R3-多柔比星。然后，在惰性气氛下，在极性无水溶剂中，在约30℃至约100℃的温度范围内，用过渡金属催化剂对4-去甲基-4-R3-磺酰基-多柔比星进行还原。保护的4-去甲氧基-4-R-多柔霉素然后在碱性溶液中经过水解，形成4-R-取代蒽环素。这种新方法省略了在缺乏立体特异性的情况下形成脱糖基和氨基糖苷之间的立体特异性糖苷键的步骤。该方法还将最终产物的产率提高了30%至40%。
• METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND
  申请人：DOT Therapeutics-1, Inc.

  公开号：US20200317659A1

  公开（公告）日：2020-10-08

  The aim of the present invention is to provide a method capable of producing an optically active pyrimidinamide derivative on an industrial scale. Compound (I) or a salt thereof is subjected to an asymmetric reduction reaction, the obtained compound (II) or a salt thereof is subjected to a deprotection reaction, and the obtained compound (III) or a salt thereof is reacted with compound (VI) or a salt thereof to obtain compound (V) or a salt thereof. wherein each symbol is as defined in the specification.

  本发明的目的是提供一种能够在工业规模上生产光学活性嘧啶酰胺衍生物的方法。化合物（I）或其盐经过不对称还原反应，得到的化合物（II）或其盐经过去保护反应，得到的化合物（III）或其盐与化合物（VI）或其盐反应，得到化合物（V）或其盐，其中每个符号如规范中定义的那样。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE AMINE
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20150210657A1

  公开（公告）日：2015-07-30

  A process for producing an optically active amine compound, characterized by asymmetrically hydrogenating a prochiral carbon-nitrogen double bond in the presence of a ruthenium complex represented by general formula (1) or (2) (wherein P represents an optically active diphosphine, X represents an anionic group, and Ar represents an optionally substituted arylene group).

  一种制备光学活性胺化合物的方法，其特征在于在存在由通用式（1）或（2）表示的钌配合物的情况下，对一个丙半胱氨基双键进行不对称氢化（其中P代表光学活性二膦，X代表阴离子基团，Ar代表可选择取代的芳基基团）。