5-(2,3-dihydro-1,4-benzodioxan-6-yl)-5-ethyl-3-[4-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-(4-methoxyphenethyl)phenyloxy]butyl]imidazolidine-2,4-dione | 1031399-54-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-(2,3-dihydro-1,4-benzodioxan-6-yl)-5-ethyl-3-[4-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-(4-methoxyphenethyl)phenyloxy]butyl]imidazolidine-2,4-dione
• 英文别名: 5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-ethyl-3-[4-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-[2-(4-methoxyphenyl)ethyl]phenoxy]butyl]imidazolidine-2,4-dione
• CAS: 1031399-54-8
• 化学式: C₃₅H₃₆F₆N₂O₇
• 分子量: 710.67
• InChiKey: SJIOOGWSUOSZKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  50
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  13

文献信息

• SUBSTITUTED CARBINOL COMPOUND
  申请人：Kowa Company. Ltd.

  公开号：EP2098515A1

  公开（公告）日：2009-09-09

  There is provided a novel LXRβ agonist useful as a preventative and/or therapeutic agent for arteriosclerosis; arteriosclerosis such as those resulting from diabetes; hyperlipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases caused by inflammatory cytokines, skin diseases such as allergic skin diseases, diabetes or Alzheimer's disease. The agonist is a carbinol derivative represented by the following general formula (1) or salt thereof, or their solvate.

  本发明提供了一种新型 LXRβ 激动剂，可用作动脉硬化的预防和/或治疗剂；动脉硬化如糖尿病引起的动脉硬化；高脂血症；高胆固醇血症；脂质相关疾病；由炎性细胞因子引起的炎症性疾病；皮肤病如过敏性皮肤病、糖尿病或阿尔茨海默病。激动剂是由以下通式(1)或其盐或它们的溶解物代表的醇衍生物。
• US8168666B2
  申请人：——

  公开号：US8168666B2

  公开（公告）日：2012-05-01