(2R,3S,4S,5R,6R)-6-((2R,3R,4S,5R)-6-Acetoxy-2-acetoxymethyl-5-benzyloxy-4-methoxy-tetrahydro-pyran-3-yloxy)-5-benzoyloxy-4-methoxy-3-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-carboxylic acid benzyl ester | 195306-11-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4S,5R,6R)-6-((2R,3R,4S,5R)-6-Acetoxy-2-acetoxymethyl-5-benzyloxy-4-methoxy-tetrahydro-pyran-3-yloxy)-5-benzoyloxy-4-methoxy-3-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-carboxylic acid benzyl ester
• CAS: 195306-11-7
• 化学式: C₄₄H₅₀O₁₇
• 分子量: 850.871
• InChiKey: GYEGLDXVMWCIQL-PJSFKYGLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.81
• 重原子数：
  61.0
• 可旋转键数：
  19.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  203.95
• 氢给体数：
  0.0
• 氢受体数：
  17.0

反应信息

• 作为反应物：
  描述：

  (2R,3S,4S,5R,6R)-6-((2R,3R,4S,5R)-6-Acetoxy-2-acetoxymethyl-5-benzyloxy-4-methoxy-tetrahydro-pyran-3-yloxy)-5-benzoyloxy-4-methoxy-3-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-carboxylic acid benzyl ester 在 苄胺 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 (2R,3S,4S,5R,6R)-6-((2R,3R,4S,5R)-2-Acetoxymethyl-5-benzyloxy-6-hydroxy-4-methoxy-tetrahydro-pyran-3-yloxy)-5-benzoyloxy-4-methoxy-3-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-carboxylic acid benzyl ester
  参考文献：
  名称：

  A synthetic heparin/heparan sulfate-like decasaccharide releases lipase activity in vivo. Chemical synthesis and biological activity

  摘要：

  A decasaccharide mimic of the heparan sulfate fragment reported to have high affinity for lipoprotein lipase has been synthesised, and shown to release lipase activity in vivo in the rat. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00361-2
• 作为产物：
  描述：

  乙酸酐 、 methyl O-(benzyl 2-O-benzoyl-4-O-levulinyl-3-O-methyl-α-L-idopyranosyluronate)-(1->4)-2,6-di-O-benzyl-3-O-methyl-α-D-glucopyranoside 在 硫酸 作用下， 反应 0.25h， 生成 (2R,3S,4S,5R,6R)-6-((2R,3R,4S,5R)-6-Acetoxy-2-acetoxymethyl-5-benzyloxy-4-methoxy-tetrahydro-pyran-3-yloxy)-5-benzoyloxy-4-methoxy-3-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-carboxylic acid benzyl ester
  参考文献：
  名称：

  A synthetic heparin/heparan sulfate-like decasaccharide releases lipase activity in vivo. Chemical synthesis and biological activity

  摘要：

  A decasaccharide mimic of the heparan sulfate fragment reported to have high affinity for lipoprotein lipase has been synthesised, and shown to release lipase activity in vivo in the rat. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00361-2