2.4.6-Triiod-3.5-bis-acetamino-benzoesaeure-(1-carboxy-pentylester) | 19005-79-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2.4.6-Triiod-3.5-bis-acetamino-benzoesaeure-(1-carboxy-pentylester)
• 英文别名: 2-(3,5-Diacetamido-2,4,6-triiodobenzoyl)oxyhexanoic acid
• CAS: 19005-79-9
• 化学式: C₁₇H₁₉I₃N₂O₆
• 分子量: 728.061
• InChiKey: MAEKXFSMTNVAKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Composition of and method for preparing stable particles in a frozen aqueous matrix
  申请人：——

  公开号：US20030077329A1

  公开（公告）日：2003-04-24

  The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The composition is stable for a prolonged period of time, preferably six months or longer and is suitable for parenteral, oral, or non-oral routes such as pulmonary (inhalation), ophthalmic, or topical administration.

  本发明揭示了一种稳定的悬浮液组合物，其包含一种难溶于水的药物或化妆品，以药物或化妆品的颗粒形式悬浮于冻结水基体中，并揭示了其制备方法。该组合物稳定性长时间，优选为六个月或更长时间，适用于静脉、口服或非口服途径，例如肺部（吸入）、眼科或局部给药。
• COMPOSITION OF AND METHOD FOR PREPARING STABLE PARTICLES IN A FROZEN AQUEOUS MATRIX
  申请人：Kipp E. James

  公开号：US20060222710A1

  公开（公告）日：2006-10-05

  The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The composition is stable for a prolonged period of time, preferably six months or longer and is suitable for parenteral, oral, or non-oral routes such as pulmonary (inhalation), ophthalmic, or topical administration.

  本发明揭示了一种稳定的悬浮液组合物，该组合物以制药剂或化妆品的颗粒形式悬浮于冻结的水基基质中，并提供了其制备方法。该组合物稳定性能长时间保持，最好为六个月或更长时间，并适用于肠道内、口服或非口服途径，如肺部（吸入）、眼科或局部给药。
• X-ray contrast compositions useful in medical imaging
  申请人：NanoSystems L.L.C.

  公开号：EP0498482A2

  公开（公告）日：1992-08-12

  An X-ray contrast composition comprising particles consisting essentially of a non-radioactive crystalline organic x-ray contrast agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than 400 nm, and a pharmaceutically acceptable carrier therefor is useful in x-ray diagnostic medical imaging methods. The agents can be delivered to a specific tissue or fluid site, for example, the blood pool, liver, spleen, kidney or lymph nodes. In one embodiment involving intravenous administration, preferred compositions provide effective imaging of the blood pool for remarkably long times.

  一种 X 射线造影剂组合物，其颗粒主要由一种非放射性结晶有机 X 射线造影剂组成，该造影剂表面吸附有表面改性剂，其吸附量足以保持有效平均粒径小于 400 纳米，该组合物还包括一种药学上可接受的载体，可用于 X 射线诊断医学成像方法。这些制剂可被输送到特定的组织或液体部位，例如血液池、肝脏、脾脏、肾脏或淋巴结。在一个涉及静脉给药的实施方案中，优选的组合物可在相当长的时间内对血液池进行有效成像。
• Reduction of intravenously administered nanoparticulate-formulation-induced adverse physiological reactions
  申请人：Elan Pharma International Limited

  公开号：EP2275094A2

  公开（公告）日：2011-01-19

  Disclosed are methods of intravenous administration of nanoparticulate drug formulations to a mammal to avoid adverse hemodynamic effects: by reducing the rate and concentration of the nanoparticles in the formulations; or by pretreating the subject with histamine; or by pretreating the subject with a desensitizing amount of the nanoparticulate drug formulations.

  公开了向哺乳动物静脉注射纳米颗粒药物制剂以避免不良血液动力学效应的方法：通过降低制剂中纳米颗粒的速率和浓度；或通过用组胺预处理受试者；或通过用脱敏量的纳米颗粒药物制剂预处理受试者。
• Nanoparticulate beclomethasone dipropionate compositions
  申请人：Elan Pharma International Ltd.

  公开号：US20040057905A1

  公开（公告）日：2004-03-25

  There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.

  本发明公开了一种气溶胶，包括纳米粒子水分散液的液滴，所述纳米粒子包括不溶性治疗或诊断剂粒子，其表面具有表面改性剂。还公开了一种制造气溶胶的方法以及使用该气溶胶进行治疗和诊断的方法。