tert-butyl N-[1-(4-bromophenyl)-1-hydroxypropan-2-yl]carbamate | 1956356-30-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-[1-(4-bromophenyl)-1-hydroxypropan-2-yl]carbamate
• CAS: 1956356-30-1
• 化学式: C₁₄H₂₀BrNO₃
• 分子量: 330.22
• InChiKey: YBDRDRQTMDZILY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• NON-STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS FOR LOCAL DRUG DELIVERY
  申请人：LEO Pharma A/S

  公开号：US20180258080A1

  公开（公告）日：2018-09-13

  The present invention relates to a compound according to formula (I) wherein R 1 is selected from the group consisting of 5- and 6-membered heteroaryl, (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (4-6)-membered heterocycloalkyl and phenyl; R 2 is selected from (C 1 -C 3 )alkyl and halo(C 1 -C 3 )alkyl; R 3 is selected from phenyl, 5-membered heteroaryl and 6-membered heteroaryl; R 4 is selected from hydrogen, halogen, (C 1 -C 4 )alkyl and halo(C 1 -C 4 )alkyl; X 1 is selected from CH, C(R b ) and N, X 2 is selected from CH and N; Y is selected from —NH— and —O—; m is 0 or 1; n is 0 or 1; L represents a bond, —O—, —NH— or —N(R c )—; or pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to intermediates for the preparation of said compounds, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.