1-[4-(methoxymethyl)phenyl]-N,N-dimethylmethanamine | 132719-07-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[4-(methoxymethyl)phenyl]-N,N-dimethylmethanamine
• CAS: 132719-07-4
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: QNBOKZUJAIRHJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 (4-(甲氧基甲基)苯基)甲胺 在 甲酸 作用下， 生成 1-[4-(methoxymethyl)phenyl]-N,N-dimethylmethanamine
  参考文献：
  名称：

  Chemical ionization mass spectrometry of bifunctional compounds. The behaviour of bifunctional compounds on protonation

  摘要：

  AbstractPositive‐ion chemical ionization mass spectra were measured for simple bifunctional aromatic compounds of the type p‐XCH2C6H4CH2Y, where X = NH2, NH(CH3) and N(CH3)2 and Y = OH and OCH3. For each compound, essentially only three peaks of ions, [MH]+, [ MH ‐ XH] + and [MH ‐ YH] +, appeared. The B/E con stant linked‐scan spectra showed that the stable non‐decomposing [MH]+ had the proton only on the nitrogen‐containing functional group. From these data, the relative amounts of total protonation, the ratio of N‐and O‐protonation and the fraction of fragmenting [MH]+ can be calculated. The ease of protonation (protonation susceptibility) and the reactivity (fragmentation capability) of the respective functional groups are discussed.

  DOI：

  10.1002/oms.1210251205

文献信息

• [EN] NTCP INHIBITORS<br/>[FR] INHIBITEURS DE NTCP
  申请人：NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING

  公开号：WO2019196953A1

  公开（公告）日：2019-10-17

  Provided are cyclosporin A analogues that are NTCP inhibitors and useful for treating HBV and/or HDV infection (s), hepatoprotection and amelioration of hypercholesterolemia, diabetes and inhibiting cancer.

  提供的环孢霉素A类似物是NTCP抑制剂，可用于治疗HBV和/或HDV感染，肝脏保护和改善高胆固醇血症、糖尿病以及抑制癌症。
• NTCP inhibitors
  申请人：National Institute of Biological Sciences, Beijing

  公开号：US10961231B2

  公开（公告）日：2021-03-30

  The invention provides cyclosporin A analogues that are NTCP inhibitors and useful for treating HBV and/or HDV infection(s), hepatoprotection and amelioration of hypercholesterolemia, diabetes and inhibiting cancer.

  本发明提供的环孢素 A 类似物是 NTCP 抑制剂，可用于治疗 HBV 和/或 HDV 感染、保肝、改善高胆固醇血症、糖尿病和抑制癌症。
• METHODS AND COMPOSITIONS FOR THE TREATMENT OF BCR-ABL POSITIVE LYMPHOBLASTIC LEUKEMIAS
  申请人：ST. JUDE CHILDREN'S RESEARCH HOSPITAL

  公开号：US20150133462A1

  公开（公告）日：2015-05-14

  In one aspect, the invention relates to compositions comprising BCR-ABL tyrosine kinase inhibitors and artemisinin analogues, derivatives thereof, or related compounds, which are useful as in treating Philadelphia chromosome positive leukemias; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with BCR-ABL dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• NTCP Inhibitors
  申请人：National Institute of Biological Sciences, Beijing

  公开号：US20210040072A1

  公开（公告）日：2021-02-11

  The invention provides cyclosporin A analogues that are NTCP inhibitors and useful for treating HBV and/or HDV infection(s), hepatoprotection and amelioration of hypercholesterolemia, diabetes and inhibiting cancer.
• US9801851B2
  申请人：——

  公开号：US9801851B2

  公开（公告）日：2017-10-31