2-nitrobenzyl benzohydroxamate | 36663-91-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-nitrobenzyl benzohydroxamate
• 英文别名: Benzhydroxamsaeure-<2-nitro-benzylaether>；Benzhydroxamsaeure-(2-nitro-benzylaether)；N-[(2-nitrophenyl)methoxy]benzamide
• CAS: 36663-91-9
• 化学式: C₁₄H₁₂N₂O₄
• 分子量: 272.26
• InChiKey: VFGZKITYGUSYBC-UHFFFAOYSA-N

物化性质

• 熔点：
  119-120 °C(Solv: ethanol (64-17-5))
• 密度：
  1.304±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-nitrobenzyl benzohydroxamate 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 O-(2-nitrobenzyl)hydroxylamine
  参考文献：
  名称：

  45.氨基氧基衍生物。第二部分 N-羟基二胍的一些衍生物

  摘要：

  DOI：

  10.1039/jr9600000229
• 作为产物：
  描述：

  2-硝基苄溴 在 sodium hydroxide 作用下， 以 水 、 乙醇 为溶剂， 反应 2.0h， 生成 2-nitrobenzyl benzohydroxamate
  参考文献：
  名称：

  [EN] 1-ALKOXY 1H-IMIDAZO RING SYSTEMS AND METHODS
  [FR] SYSTEMES CYCLIQUES 1-ALCOXY 1 H -IMIDAZO ET PROCEDES ASSOCIES

  摘要：

  公开号：

  WO2006028962A3

文献信息

• New calcium antagonists: synthesis, X-ray analysis, and smooth muscle relaxing effect of 3-[ O -(Benzyl-substituted)-oximino-ethers]-hexahydroazepin-2,3-diones
  作者：Hayat El From、Marie-Hélène Péra、Gérard Leclerc、Duc Tranqui、Emmanuelle Corompt、Germain Bessard、Philippe Devillier

  DOI：10.1016/s0968-0896(99)00090-5

  日期：1999.8

  trachea and human bronchus. This derivative acts mainly by inhibiting cellular influx of extracellular calcium since it inhibits potently and dose-dependently the contractions of rat trachea to high concentrations of KCI and to CaCl2 in a depolarizing medium. It appears to act weakly by inducing cGMP and cAMP synthesis. Moreover, its relaxing activity is not related to an inhibition of phosphodiesterases

  由相应的六氢a庚因-2，3-二酮制备了一系列新的Z和E 3- [O-（苄基取代的-肟基醚）-六氢hydro庚因-2，3-二酮，并作为平滑肌松弛剂进行了测试。E和Z结构通过NMR分析确定，并通过使用同步加速器辐射的X射线衍射确定16（E和Z）。硝基苄基衍生物16是体外最有效的用乙酰胆碱预收缩的大鼠气管松弛剂。E异构体16b比Z异构体16a更有效。E异构体16b比氨茶碱更有效地松弛大鼠气管和人支气管。该衍生物主要通过抑制细胞外钙的流入而起作用，因为它在去极化介质中有效和剂量依赖性地抑制大鼠气管收缩至高浓度的KCI和CaCl2。它似乎通过诱导cGMP和cAMP合成而作用较弱。而且，其松弛活性与磷酸二酯酶的抑制，钾通道的开放或前列腺素合成的诱导无关。因此，16b似乎主要作为有效的钙拮抗剂起作用。
• The effect of nitro substitution on the photochemistry of benzyl benozhydroxamate: Photoinduced release of benzohydroxamic acid
  作者：Whitney R. Grither、James Korang、Jacob P. Sauer、Matthew P. Sherman、Pamela L. Vanegas、Miao Zhang、Ryan D. McCulla

  DOI：10.1016/j.jphotochem.2011.10.005

  日期：2012.1

  The redox congener of the important signaling agent nitric oxide (NO), nitroxyl or nitrosyl hydride (HNO) has also been demonstrated to induce distinct physiological effects. The aim of this study was to determine if benzohydroxamic acid, which was selected as a stable model compound of HNO donors, could be released by the o-nitrobenzyl photolabile protecting group (PPG) in a wavelength-dependent manner. It was expected that selective irradiation of the o-nitrobenzyl chromophore would favor the release of benzohydroxamic acid over undesired products associated with N-O bond cleavage. Quantum yields for the release of benzohydroxamic acid protected by the o-nitrobenzyl PPG increased at longer wavelengths, with a concomitant decrease in the yield of minor products. Through the use of triplet photosensitizers, triplet quenchers, computational methods, and the position of the nitro substituent, insights into the nature of the mechanism were suggested. (C) 2011 Elsevier B.V. All rights reserved.
• HOMOPOLYMER ENCODED NUCLEIC ACID MEMORY
  申请人：Molecular Assemblies, Inc.

  公开号：US20190344239A1

  公开（公告）日：2019-11-14

  Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.
• [EN] HOMOPOLYMER ENCODED NUCLEIC ACID MEMORY<br/>[FR] MÉMOIRE D'ACIDE NUCLÉIQUE ENCODÉE PAR UN HOMOPOLYMÈRE
  申请人：MOLECULAR ASSEMBLIES INC

  公开号：WO2020219853A1

  公开（公告）日：2020-10-29

  Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.