苯甲醛-一聚乙二醇-琥珀酰亚胺酯 | 2101206-80-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯甲醛-一聚乙二醇-琥珀酰亚胺酯
• 英文名称: Ald-Ph-amido-PEG1-C2-NHS ester
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 3-[2-[(4-formylbenzoyl)amino]ethoxy]propanoate
• CAS: 2101206-80-6
• 化学式: C₁₇H₁₈N₂O₇
• 分子量: 362.3
• InChiKey: ONVNDJSKJDFLTF-UHFFFAOYSA-N

物化性质

• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  7

制备方法与用途

生物活性

Ald-Ph-amido-PEG1-C2-NHS ester 是一种不可降解的含 1 个单元 PEG 的 linker，可用于合成抗体偶联药物 (ADC) 。

靶点

Non-cleavable

文献信息

• Anti-CD276 antibodies (B7H3)
  申请人：THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH

  公开号：US10604582B2

  公开（公告）日：2020-03-31

  Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of (a) cancer or (b) tumor vasculature in a mammal and methods of (a) treating or preventing cancer or (b) reducing tumor vasculature in a mammal are also disclosed.

  本研究公开了能与 CD276 特异性结合并在免疫学上识别 CD276 的多肽和蛋白质。还公开了嵌合抗原受体（CAR）、抗 CD276 结合分子、核酸、重组表达载体、宿主细胞、细胞群、药物组合物以及与多肽和蛋白质有关的共轭物。还公开了检测哺乳动物体内是否存在(a)癌症或(b)肿瘤血管的方法，以及(a)治疗或预防哺乳动物体内癌症或(b)减少肿瘤血管的方法。
• ANTI-CD276 ANTIBODIES (B7H3)
  申请人：The U.S.A. as represented by the Secretary, Department of Health and Human Services

  公开号：EP3193933B1

  公开（公告）日：2021-04-28
• HETEROBIFUNCTIONAL LINKERS WITH POLYETHYLENE GLYCOL SEGMENTS AND IMMUNE RESPONSE MODIFIER CONJUGATES MADE THEREFROM
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US20170037045A1

  公开（公告）日：2017-02-09

  Conjugates of an immune response modifier, a linker, and an antigen are disclosed. The linker is represented by formula: wherein A is CH or N, p is in a range from 1 to 50, R″ is a bond or -alkylene-O—, R′ is alkylene that is optionally interrupted or terminated with one or more amide or ether groups, and E is an amine- or thiol-reactive group. Pharmaceutical compositions containing the compound or the conjugate, methods of making a conjugate, and methods of use of the compounds or conjugates as immunomodulators for inducing cytokine biosynthesis in an animal and for vaccinating an animal are also disclosed. An antigen modified by the linker is also disclosed.
• US9902724B2
  申请人：——

  公开号：US9902724B2

  公开（公告）日：2018-02-27
• [EN] ANTI-CD276 ANTIBODIES (B7H3)<br/>[FR] ANTICORPS ANTI-CD276 (B7H3)
  申请人：US HEALTH

  公开号：WO2016044383A1

  公开（公告）日：2016-03-24

  Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of (a) cancer or (b) tumor vasculature in a mammal and methods of (a) treating or preventing cancer or (b) reducing tumor vasculature in a mammal are also disclosed.