N-(3,5-dimethylphenyl)-1-(pyrimidin-2-yl)-1H-pyrrole-2-sulfonamide | 1251534-00-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,5-dimethylphenyl)-1-(pyrimidin-2-yl)-1H-pyrrole-2-sulfonamide
• 英文别名: N-(3,5-Dimethylphenyl)-1-(2-pyrimidinyl)-1H-pyrrole-2-sulfonamide；N-(3,5-dimethylphenyl)-1-pyrimidin-2-ylpyrrole-2-sulfonamide
• CAS: 1251534-00-5
• 化学式: C₁₆H₁₆N₄O₂S
• 分子量: 328.395
• InChiKey: RWIIQMDQYAZUPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  85.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE
  申请人：Agios Pharmaceuticals, Inc.

  公开号：EP2417123A2

  公开（公告）日：2012-02-15
• PYRUVATE KINASE M2 MODULATORS, THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE
  申请人：Salituro Francesco G.

  公开号：US20120122885A1

  公开（公告）日：2012-05-17

  Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
• ACTIVATORS OF PYRUVATE KINASE M2 AND METHODS OF TREATING DISEASE
  申请人：Kung Charles

  公开号：US20140249150A1

  公开（公告）日：2014-09-04

  The invention described herein features methods, compositions, and kits that utilize activators of pyruvate kinase M2 (PKM2) for the treatment or amelioration of disorders related to PKM2 function and characterized by abnormally low levels of serine.
• US8742119B2
  申请人：——

  公开号：US8742119B2

  公开（公告）日：2014-06-03
• US9657004B2
  申请人：——

  公开号：US9657004B2

  公开（公告）日：2017-05-23