2,3,4-tri-O-benzyl-6-O-p-methoxybenzyl-α-D-galactopyranose | 1330629-57-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,4-tri-O-benzyl-6-O-p-methoxybenzyl-α-D-galactopyranose
• CAS: 1330629-57-6
• 化学式: C₃₅H₃₈O₇
• 分子量: 570.683
• InChiKey: IABJPUFUJVWMQU-NVCPMKERSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.69
• 重原子数：
  42.0
• 可旋转键数：
  14.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  75.61
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  phenyl 2,3,4-tri-O-benzyl-6-O-(4-methoxyphenyl)methyl-1-thio-β-D-galactopyranoside 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 水 、 丙酮 为溶剂， 反应 0.33h， 生成 2,3,4-tri-O-benzyl-6-O-p-methoxybenzyl-β-D-galactopyranose 、 2,3,4-tri-O-benzyl-6-O-p-methoxybenzyl-α-D-galactopyranose
  参考文献：
  名称：

  Sequential one-pot glycosylation with glycosyl N-trichloroacetylcarbamate and trichloroacetate including dehydrative approach using 1-hydroxy sugars

  摘要：

  An efficient sequential one-pot glycosylation has been developed with glycosyl trichlorocarbamate and trichloroacetate activated by the same Lewis acid and enabled by a change in reaction temperature. The act-selective glycosylation was achieved using glucose, galactose, and mannose substrates after investigation into the reactivities of the two types of glycosyl donors. Sequential one-pot dehydrative glycosylation, including in situ preparation of glycosyl donors followed by generation of two glycosyl bonds, provided three types of trisaccharide. (C) 2011 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2011.06.006