trans-1-acetoxy-4-(N-phenylsulfonyl-N-methallylamino)cyclohex-2-ene | 136523-88-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trans-1-acetoxy-4-(N-phenylsulfonyl-N-methallylamino)cyclohex-2-ene
• CAS: 136523-88-1
• 化学式: C₁₈H₂₃NO₄S
• 分子量: 349.451
• InChiKey: YSYUVSPTZDIJNZ-IAGOWNOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  63.68
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  trans-1-acetoxy-4-(N-phenylsulfonyl-N-methallylamino)cyclohex-2-ene 在 palladium diacetate 三苯基膦 作用下， 以 苯甲醚 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Palladium catalysed tandem cyclisation-anion capture processes. Part 3. Organoboron anion transfer agents

  摘要：

  The cyclisation-anion capture protocol has been applied to a wide range of starter and terminating species to effect regio-and stereo-specific mono-and bis-cyclisation processes in which a variety of organoboronderivatives function as anion transfer reagents. Direct capture (no cyclisation) is rarely a problem and it can usually be suppressed by modification of the reaction conditions. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00754-0
• 作为产物：
  描述：

  N-phenylsulphonyl methallylamine 、 cis-1-acetoxy-4-chlorocyclohex-2-ene 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 以67%的产率得到trans-1-acetoxy-4-(N-phenylsulfonyl-N-methallylamino)cyclohex-2-ene
  参考文献：
  名称：

  Palladium catalysed tandem cyclisation-anion capture processes. Part 3. Organoboron anion transfer agents

  摘要：

  The cyclisation-anion capture protocol has been applied to a wide range of starter and terminating species to effect regio-and stereo-specific mono-and bis-cyclisation processes in which a variety of organoboronderivatives function as anion transfer reagents. Direct capture (no cyclisation) is rarely a problem and it can usually be suppressed by modification of the reaction conditions. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00754-0

文献信息

• Palladium catalysed tandem cyclisation-anion capture processes initiated by alkyl- and π-allyl-palladium species
  作者：Ronald Grigg、Sukanthini Sukirthalingam、Visuvanathar Sridharan

  DOI：10.1016/s0040-4039(00)74377-2

  日期：1991.11

  Palladium catalysed tandem cyclisation-anion capture processes initiated by oxidative addition of benzylic or allylic halides or acetates to Pd(O) occure regio- and stereo- specifically in good yield. Examples of “anion” capture involving formate (H−), and organo - tin, -zinc, and -boron species are described.

  通过将苄基或烯丙基卤化物或乙酸盐氧化添加到Pd（O）中引发的钯催化的串联环化-阴离子捕获过程特别以良好的产率在区域和立体上发生。（H“阴离子”捕获涉及甲酸的实例- ），和有机-锡， -锌，和-硼物种中有描述。