(S)-tert-butyl 3-(2-bromoethyl)pyrrolidine-1-carboxylate | 1421026-17-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (S)-tert-butyl 3-(2-bromoethyl)pyrrolidine-1-carboxylate
• 英文别名: tert-butyl (3S)-3-(2-bromoethyl)pyrrolidine-1-carboxylate
• CAS: 1421026-17-6
• 化学式: C₁₁H₂₀BrNO₂
• 分子量: 278.19
• InChiKey: SEFXLCQXQDYFPR-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] QUINAZOLINE DERIVATIVES WITH HSP90 INHIBITORY ACTIVITY<br/>[FR] DÉRIVÉS DE QUINAZOLINE À ACTIVITÉ INHIBITRICE DE HSP90
  申请人：DAC SRL

  公开号：WO2013064919A1

  公开（公告）日：2013-05-10

  Compounds of general formula (I): or a stereoisomer, tautomer, polymorph, hydrate, solvate, or a pharmaceutically acceptable salt thereof, wherein R is as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as proliferative diseases, e.g. cancers, viral and fungal infections, neurodegenerative or inflammatory diseases or conditions. The invention also relates to the preparation of these compounds as well as to pharmaceutical compositions comprising them.