1,3,5-tris(4-cyclohexylphenyl)benzene | 1353748-00-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3,5-tris(4-cyclohexylphenyl)benzene
• CAS: 1353748-00-1
• 化学式: C₄₂H₄₈
• 分子量: 552.843
• InChiKey: ABVAUUBKBYNQHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.4
• 重原子数：
  42
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  4'-环己基苯乙酮 在 nano-silica sulfuric acid 作用下， 以 neat (no solvent) 为溶剂， 反应 0.25h， 以90%的产率得到1,3,5-tris(4-cyclohexylphenyl)benzene
  参考文献：
  名称：

  Nano-silica sulfuric acid catalyzed the efficient synthesis of 1,3,5-triarylbenzenes under microwave irradiation

  摘要：

  纳米二氧化硅硫酸作为异相、环保且可重复使用的催化剂，被用于通过乙酰苯的三重自缩合反应合成1,3,5-三芳基苯。所有反应均在无溶剂条件和微波辐射下进行。短反应时间、高产率、产品易于分离和纯化以及该催化剂的良好重复性是制备1,3,5-三芳基苯选择这种催化剂的主要原因。

  DOI：

  10.1007/s13738-012-0089-0

文献信息

• DBSA catalyzed cyclotrimerization of acetophenones: An efficient synthesis of 1,3,5-triarylbenzenes under solvent-free conditions
  作者：Davinder Prasad、Amreeta Preetam、Mahendra Nath

  DOI：10.1016/j.crci.2012.12.008

  日期：2013.3

  Résumé A facile method for the synthesis of 1,3,5-triarylbenzenes is developed via cyclotrimerization of acetophenones in the presence of 4-dodecylbenzenesulfonic acid (DBSA) as an efficient Bronsted acid catalyst under solvent-free conditions. This synthetic protocol has several advantages such as green reaction conditions, short reaction times, high atom economy and good to excellent yields of the target products. Supplementary Materials: Supplementary material for this article is supplied as a separate file: mmc1.doc

  简历 摘要 一种简便的方法是通过在无溶剂条件下，以4-十二烷基苯磺酸（DBSA）作为高效的布朗斯台德酸催化剂，通过苯乙酮的环三聚反应合成1,3,5-三苯基苯。该合成方案具有绿色反应条件、短反应时间、高原子经济性和良好至优异的目标产物产率等优点。 补充材料： 与本文相关的补充材料作为一个单独的文件提供：mmc1.doc
• Microwave-promoted efficient conversion of acetophenones to 1,3,5-triarylbenzenes catalyzed by H3PW12O40 and nano-silica supported H3PW12O40 as reusable catalysts
  作者：Rashid Ghanbaripour、Iraj Mohammadpoor-Baltork、Majid Moghadam、Ahmad R. Khosropour、Shahram Tangestaninejad、Valiollah Mirkhani

  DOI：10.1016/j.poly.2011.10.027

  日期：2012.1

  H3PW12O40 and nano-silica supported H3PW12O40 were found to be efficient heterogeneous catalysts for the preparation of 1,3,5-triarylbenzenes via triple self condensation of acetophenones under microwave irradiation and solvent-free conditions. High yields, short reaction times, easy work-up, easy availability and handling, eco-friendly and reusability of the catalysts are the main aspects of the present method. The catalytic mechanism of 1,3,5-triarylbenzenes synthesis is also proposed. (C) 2011 Elsevier Ltd. All rights reserved.