(2S,5S)-1,2,5-trimethylphospholane | 1403557-33-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 金属杂环化合物
• 英文名称: (2S,5S)-1,2,5-trimethylphospholane
• CAS: 1403557-33-4
• 化学式: C₇H₁₅P
• 分子量: 130.17
• InChiKey: YWYRRVMHCNOFAN-BQBZGAKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  di(rhodium)tetracarbonyl dichloride 、 (2S,5S)-1,2,5-trimethylphospholane 以 二氯甲烷 为溶剂， 生成 trans-[RhCl(CO)((2S,5S)-1,2,5-trimethylphospholane)₂]
  参考文献：
  名称：

  基于膦烷结构的手性单齿三烷基膦

  摘要：

  有效的手性单齿膦配体的发展落后于二齿同类物。对于能够在催化不对称转化中取代普遍存在的三环己基膦和三叔丁基膦的高度富电子的手性膦类似物尤其如此。我们提出了基于流行的膦酸酯骨架的一组具有不同空间需求的手性单齿配体的方便和模块化的合成。它们的空间和电子性质由其相应的镍和钯配合物确定。它们代表了流行的三环己基膦和三叔丁基膦配体的良好模拟物。随后在钯催化的不对称C（sp 3）– H功能化导致二氢吲哚。

  DOI：

  10.1021/om3008772

文献信息

• PROCESS FOR THE HYDROGENATION OF IMINES
  申请人：Saaby Steen

  公开号：US20110077418A1

  公开（公告）日：2011-03-31

  A process is provided for the hydrogenation of imines with hydrogen under elevated pressure in the presence of iridium complexes as catalysts and one or more co-catalysts selected among compounds comprising a carbon-halogen bond. Further provided are novel ligands and metal complexes thereof useful for the catalytic hydrogenation of imines with hydrogen. The novel ligands are compounds of the formula (VII) or formula (VIII) in the form of racemates, mixtures of stereoisomers or optically pure stereoisomers wherein the radicals are as defined in the specification.

  提供了一种在铱络合物存在下，在高压下利用氢气对亚胺进行加氢的方法，并选择一种或多种在其中的协同催化剂，所述协同催化剂选自包含碳-卤素键的化合物。还提供了用于催化亚胺与氢气加氢的新型配体和金属络合物。这些新型配体是根据式（VII）或式（VIII）的化合物，以外消旋体、立体异构体混合物或光学纯立体异构体的形式存在，其中基团如规范中所定义。
• CATALYSTS FOR THE POLYMERIZATION OF CYCLIC ESTERS
  申请人：Hayes Paul G.

  公开号：US20100130753A1

  公开（公告）日：2010-05-27

  The present disclosure relates to cationic divalent metal catalysts useful for the polymerization of cyclic esters, methods for their preparation and uses thereof.

  本公开涉及用于环酯聚合的阳离子二价金属催化剂，其制备方法及用途。
• METHOD FOR THE HOMOGENEOUS CATALYTIC REDUCTIVE AMINATION OF CARBONYL COMPOUNDS
  申请人：BASF SE

  公开号：US20180186725A1

  公开（公告）日：2018-07-05

  The present invention relates to a method for the reductive amination of a carbonyl compound, comprising one or more carbonyl groups amenable to reductive amination, forming the corresponding primary amine, characterized in that the reaction is carried out in the presence of a homogeneously dissolved catalyst complex K, comprising at least one metal atom from Group 8, 9 or 10 of the periodic table, bearing a bidentate phosphane ligand, a carbonyl ligand, a neutral ligand and a hydride ligand, and also an acid as co-catalyst.

  本发明涉及一种用于还原胺化羰基化合物的方法，包括一个或多个适宜进行还原胺化的羰基团，形成相应的一级胺，其特征在于在存在均匀溶解的催化剂复合物K的条件下进行反应，所述复合物K包括来自周期表第8、9或10族的至少一个金属原子，带有双膦配体、羰基配体、中性配体和氢化物配体，以及作为辅助催化剂的酸。
• Diphosphines and Metal Complexes
  申请人：Kesselgruber Martin

  公开号：US20090270622A1

  公开（公告）日：2009-10-29

  Compounds of the formula I or I′, where the radicals R 1 are each, independently of one another, a hydrogen atom or C 1 -C 4 -alkyl and R′ 1 , is C 1 -C 4 -alkyl; X 1 and X 2 are each, independently of one another, a sec-phosphino group; R 2 is hydrogen, R 01 R 02 R 03 Si— is halogen-, hydroxyl-, C 1 -C 8 -alkoxy- or R 04 R 05 N-substituted C 1 -C 18 -acyl or is R 06 —X 01 —C(O)—; R 01 , R 02 and R 03 are each, independently of one another, C 1 -C 12 -alkyl, unsubstituted or C 1 -C 4 -alkyl- or C 1 -C 4 -alkoxy-substituted C 6 -C 10 -aryl or C 7 -C 12 -aralkyl; R 04 and R 05 are each, independently of one another, hydrogen, C 1 -C 12 -alkyl, C 3 -C 8 -cycloalkyl, C 6 -C 10 -aryl or C 7 -C 12 -aralkyl, or R 04 and R 05 together are trimethylene, tetramethylene, pentamethylene or 3-oxapentylene; R 06 is C 1 -C 18 -alkyl, unsubstituted or C 1 -C 4 -alkyl- or C 1 -C 4 -alkoxy-substituted C 3 -C 8 -cycloalkyl, C 6 -C 10 -aryl or C 7 -C 12 -aralkyl; X 01 is —O— or —NH—; T is C-bonded C 3 -C 20 -heteroarylene; v is 0 or an integer from 1 to 4; X 1 in the heteroring of the heteroarylene is bound in the ortho position relative to the T—C* bond; and * indicates a mixture of racemic or enantiomerically pure diastereomers or pure racemic or enantiomerically pure diastereomers. The compounds are excellent chiral ligands for metal complexes as enantioselective catalysts for the hydrogenation of prochiral organic compounds.

  公式I或I'的化合物，其中基团R1分别是氢原子或C1-C4-烷基，R'1是C1-C4-烷基；X1和X2分别是sec-膦基团；R2是氢，R01R02R03Si—是卤素、羟基、C1-C8-烷氧基或R04R05N取代的C1-C18-酰基或是R06—X01—C(O)—；R01、R02和R03分别是C1-C12-烷基、未取代或C1-C4-烷基或C1-C4-烷氧基取代的C6-C10-芳基或C7-C12-芳基烷基；R04和R05分别是氢、C1-C12-烷基、C3-C8-环烷基、C6-C10-芳基或C7-C12-芳基烷基，或者R04和R05一起是三亚甲基、四亚甲基、五亚甲基或3-氧代戊亚甲基；R06是C1-C18-烷基，未取代或C1-C4-烷基或C1-C4-烷氧基取代的C3-C8-环烷基、C6-C10-芳基或C7-C12-芳基烷基；X01是—O—或—NH—；T是C键合的C3-C20-杂芳烃；v是0或1到4之间的整数；杂芳烃的异环中X1与T—C*键的正交位置相结合；*表示混合的外消旋或对映纯二对映异构体或纯外消旋或对映纯二对映异构体。这些化合物是金属配合物的优秀手性配体，用作对手性选择性催化剂，用于对不对称有机化合物的氢化。
• BIDENTATE SECONDARY PHOSPHINE OXIDE CHIRAL LIGANDS FOR USE IN ASYMMETRIC ADDITION REACTIONS
  申请人：Pugin Benoît

  公开号：US20110098485A1

  公开（公告）日：2011-04-28

  Compounds of the formula I, in the form of mixtures comprising predominantly one enantiomer or in the form of pure enantiomers, secondary phosphine-Q-P*(═O)HR 1 (I) in which secondary phosphine is a C-bonded, secondary phosphine group —P(R) 2 ; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C1-C4-alkylene skeleton, and in which base skeletons a secondary phosphine group is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C 1 -C 4 -alkylene group, and in which base skeletons a P-chiral group —P*(O)HR 1 is bonded to a carbon atom such that the phosphorus atoms are linked via 1 to 7 atoms of a carbon chain optionally interrupted by heteroatoms from the group of O, S, N, Fe or Si; P* is a chiral phosphorus atom; and R 1 is a hydrocarbon radical, a C-bonded heterohydrocarbon radical or a ferrocenyl radical, with the proviso that R 1 is an achiral ferrocenyl radical when Q is an achiral ferrocenyl base skeleton. Metal complexes of these ligands in a molar ratio of ligand to metal of about 1.3:1 to 0.9:1 are homogeneous catalysts for asymmetric addition reactions, particularly hydrogenations.

  化合物I的公式，以主要由一对映异体组成的混合物形式或纯映异体形式存在，其中二级膦-Q-P*（═O）HR1（I），其中二级膦是C-键合的二级膦基团-P（R）2；其中R在每种情况下独立地是碳氢基团或杂环碳氢基团；Q是二价的、无手性的、芳香基骨架、二价的、无手性的二茂铁基骨架、可选取代的二价环烷基或杂环烷基骨架，或C1-C4-烷基骨架，在这些基骨架中，一个二级膦基团直接键合到碳原子上，或在环状基骨架的情况下，直接键合到碳原子或通过C1-C4-烷基骨架，且在这些基骨架中，一个P-手性基团-P*（O）HR1键合到碳原子，使得磷原子通过1到7个碳链原子（可选取自O、S、N、Fe或Si的杂原子组）连接；P*是一个手性磷原子；R1是一个碳氢基团、C-键合的杂环碳氢基团或二茂铁基基团，但当Q是无手性二茂铁基骨架时，R1是一个无手性二茂铁基基团。这些配体的金属配合物在配体与金属的摩尔比约为1.3:1至0.9:1时，是不对称加成反应的均相催化剂，特别是氢化反应。