| 889663-66-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• CAS: 889663-66-5
• 化学式: C₃₃H₂₄Cl₂O₇
• 分子量: 603.455
• InChiKey: FOIFOOOODGNWKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.02
• 重原子数：
  42.0
• 可旋转键数：
  8.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  80.29
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  在 lithium hydroxide 、 草酰氯 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  A Highly Selective Fluorescent Probe for the Detection and Imaging of Peroxynitrite in Living Cells

  摘要：

  We have found a specific reaction between ketone 1 and peroxynitrite (ONOO-), rather than other reactive oxygen species and reactive nitrogen species generated in the biological system. On the basis of this reaction, we have successfully developed a new fluorescent probe HKGreen-1, which is highly selective for the detection of peroxynitrite in living cells. Before the oxidation with peroxynitrite, the dichlorofluorescein part is masked and the probe is nonfluorescent. However, upon reaction with peroxynitrite, the fluorophore is released, resulting in strong enhancement in fluorescence intensity.

  DOI：

  10.1021/ja0603756
• 作为产物：
  描述：

  2,7-dichlorofluorescein 在 potassium tert-butylate 、 potassium carbonate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 27.0h， 生成
  参考文献：
  名称：

  A Highly Selective Fluorescent Probe for the Detection and Imaging of Peroxynitrite in Living Cells

  摘要：

  We have found a specific reaction between ketone 1 and peroxynitrite (ONOO-), rather than other reactive oxygen species and reactive nitrogen species generated in the biological system. On the basis of this reaction, we have successfully developed a new fluorescent probe HKGreen-1, which is highly selective for the detection of peroxynitrite in living cells. Before the oxidation with peroxynitrite, the dichlorofluorescein part is masked and the probe is nonfluorescent. However, upon reaction with peroxynitrite, the fluorophore is released, resulting in strong enhancement in fluorescence intensity.

  DOI：

  10.1021/ja0603756

文献信息

• WO2007/41923
  申请人：——

  公开号：——

  公开（公告）日：——