2,2-Difluoro-2-(6-methylpyridin-3-yl)ethan-1-ol | 2228419-08-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,2-Difluoro-2-(6-methylpyridin-3-yl)ethan-1-ol
• 英文别名: 2,2-difluoro-2-(6-methylpyridin-3-yl)ethanol
• CAS: 2228419-08-5
• 化学式: C₈H₉F₂NO
• 分子量: 173.16
• InChiKey: YIEGEIXSYLHYIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PYRROLOPYRIMIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS
  申请人：Rugen Holdings (Cayman) Limited

  公开号：US20160075713A1

  公开（公告）日：2016-03-17

  Disclosed are chemical entities of formula I: wherein X, Y, Z, R 1 , R 3 , R 4 , R 5 and R 6 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of formula I, and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of formula I.

  本文揭示了化学实体的公式I：其中X、Y、Z、R1、R3、R4、R5和R6在此定义为NR2B亚型选择性受体拮抗剂。还揭示了包含化学实体的公式I的药物组合物，并通过给予公式I的化学实体来治疗与NR2B拮抗有关的各种疾病和障碍，例如中枢神经系统的疾病和障碍，如抑郁症。
• Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists
  申请人：Rugen Holdings (Cayman) Limited

  公开号：US10030026B2

  公开（公告）日：2018-07-24

  Disclosed are chemical entities of formula (I) wherein X, Y, Z, R1, R3, R4, R5 and R6 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of formula I.

  公开了式 (I) 的化学实体，其中 X、Y、Z、R1、R3、R4、R5 和 R6 在本文中定义为 NR2B 亚型选择性受体拮抗剂。 还公开了包含式（I）化学实体的药物组合物，以及通过施用式（I）化学实体治疗与 NR2B 拮抗相关的各种疾病和失调的方法，例如中枢神经系统疾病和失调，如抑郁症。
• DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS
  申请人：SHAPIRO Gideon

  公开号：US20170101412A1

  公开（公告）日：2017-04-13

  Disclosed are chemical entities of formula (I) wherein X, Y, Z, R 1 , R 3 , R 4 , R 5 and R 6 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of formula I.
• US9567341B2
  申请人：——

  公开号：US9567341B2

  公开（公告）日：2017-02-14
• US9968610B2
  申请人：——

  公开号：US9968610B2

  公开（公告）日：2018-05-15