2-Hydroxy-6-phenylsulfanylmethyl-benzoic acid | 1171924-35-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Hydroxy-6-phenylsulfanylmethyl-benzoic acid
• 英文别名: 2-hydroxy-6-(phenylsulfanylmethyl)benzoic acid
• CAS: 1171924-35-8
• 化学式: C₁₄H₁₂O₃S
• 分子量: 260.31
• InChiKey: YLAXWQBBDJBRJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  82.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] ANTIVIRAL SOX INHIBITORS<br/>[FR] INHIBITEURS DE SOX ANTIVIRAUX
  申请人：GERTRUDE BIOMEDICAL PTY LTD

  公开号：WO2022040719A1

  公开（公告）日：2022-03-03

  The present disclosure generally relates to antiviral compounds for use in treatment of viral associated diseases or conditions. The present disclosure also relates to processes for preparing the antiviral compounds, and uses or methods of treatment of viral associated diseases or conditions comprising the antiviral compounds. The present disclosure also provides antiviral compounds as inhibitors of SOX family transcription factors, and in particular 5 SOX18 transcription factor. In particular, the antiviral compounds are based on a biaryl benzoic acid scaffold according to Formula 1 as described herein.

  本公开涉及抗病毒化合物，用于治疗病毒相关疾病或病况。本公开还涉及制备抗病毒化合物的过程，以及包括抗病毒化合物的病毒相关疾病或病况的治疗用途或方法。本公开还提供抗病毒化合物作为SOX家族转录因子的抑制剂，特别是5个SOX18转录因子。特别地，抗病毒化合物基于如下公式1所述的双芳基苯甲酸骨架。