2-Hydroxy-6-phenethyloxymethyl-benzoic acid | 1171924-70-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Hydroxy-6-phenethyloxymethyl-benzoic acid
• 英文别名: 2-hydroxy-6-(2-phenylethoxymethyl)benzoic acid
• CAS: 1171924-70-1
• 化学式: C₁₆H₁₆O₄
• 分子量: 272.29
• InChiKey: UMSSXPZCCQXFLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• INHIBITORS OF SOX18 PROTEIN ACTIVITY FOR TREATING ANGIOGENESIS-AND/OR LYMPHANGIOGENESIS-RELATED DISEASES
  申请人：The University of Queensland

  公开号：US20190337880A1

  公开（公告）日：2019-11-07

  Disclosed are compounds of a formula provided herein that show efficacy in the inhibition of SOX18 protein activity, and in particular with respect to the ability of SOX18 to bind DNA and/or particular protein partners. Further, methods of treating angiogenesis- and/or lymphangiogenesis-related diseases, disorders or conditions, such as cancer metastasis and vascular cancers, are provided herein.

  本文提供了一种公式的化合物，显示出对SOX18蛋白活性的抑制效果，特别是与SOX18结合DNA和/或特定蛋白伙伴的能力。此外，本文还提供了治疗与血管生成和/或淋巴管生成相关的疾病、疾病或症状的方法，如癌症转移和血管癌。
• [EN] ANTIVIRAL SOX INHIBITORS<br/>[FR] INHIBITEURS DE SOX ANTIVIRAUX
  申请人：GERTRUDE BIOMEDICAL PTY LTD

  公开号：WO2022040719A1

  公开（公告）日：2022-03-03

  The present disclosure generally relates to antiviral compounds for use in treatment of viral associated diseases or conditions. The present disclosure also relates to processes for preparing the antiviral compounds, and uses or methods of treatment of viral associated diseases or conditions comprising the antiviral compounds. The present disclosure also provides antiviral compounds as inhibitors of SOX family transcription factors, and in particular 5 SOX18 transcription factor. In particular, the antiviral compounds are based on a biaryl benzoic acid scaffold according to Formula 1 as described herein.

  本公开涉及抗病毒化合物，用于治疗病毒相关疾病或病况。本公开还涉及制备抗病毒化合物的过程，以及包括抗病毒化合物的病毒相关疾病或病况的治疗用途或方法。本公开还提供抗病毒化合物作为SOX家族转录因子的抑制剂，特别是5个SOX18转录因子。特别地，抗病毒化合物基于如下公式1所述的双芳基苯甲酸骨架。