N-(3',4',5'-trifluorobiphenyl-2-yl)-3-difluoromethyl-5-fluoro-1-methylpyrazol-4-ylcarboxamide | 1045802-51-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3',4',5'-trifluorobiphenyl-2-yl)-3-difluoromethyl-5-fluoro-1-methylpyrazol-4-ylcarboxamide
• 英文别名: 3-(difluoromethyl)-5-fluoro-1-methyl-N-[2-(3,4,5-trifluorophenyl)phenyl]pyrazole-4-carboxamide
• CAS: 1045802-51-4
• 化学式: C₁₈H₁₁F₆N₃O
• 分子量: 399.295
• InChiKey: CYGFDJPWDOAVRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Method For Manufacturing Aryl Carboxamides
  申请人：Reichert Wolfgang

  公开号：US20110054183A1

  公开（公告）日：2011-03-03

  A process for preparing arylcarboxamides of the formula (I) where Ar =a mono- to trisubstituted phenyl, pyridyl or pyrazolyl ring, where the substituents are selected from halogen, C i -C 4 -alkyl and C 1 -C 4 -haloalkyl; M =thienyl or phenyl, which may bear a halogen substituent; Q =direct bond, cyclopropylene, fused bicycio[2.2.1]heptane or bicyclo[2.2.1]heptene ring; R 1 =hydrogen, halogen, C 1 -C 6 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, mono- to trisubstituted phenyl, where the substituents are selected from halogen and trifluoromethylthio, or cyclopropyl; by reacting an acid chloride of the formula (II) with an arylamine (III) in a suitable nonaqueous solvent, wherein, in the absence of an auxiliary base, a) the acid chloride (II) is initially charged, b) a pressure of from 0 to 700 mbar is established, c) the arylamine (III) is metered in in an approximately stoichiometric amount and d) the product of value is isolated.

  一种制备式(I)的芳基羧酰胺的方法，其中Ar = 单取代至三取代苯基、吡啶基或吡唑基环，取代基选自卤素、Ci-C4-烷基和C1-C4-卤代烷基；M = 噻吩基或苯基，可以带有卤素取代基；Q = 直链键、环丙烯基、融合的双环[2.2.1]庚烷或双环[2.2.1]庚烯环；R1 = 氢、卤素、C1-C6-烷基、C1-C4-烷氧基、C1-C4-卤代烷氧基、单取代至三取代苯基，其中取代基选自卤素和三氟甲硫基，或环丙基；通过在适当的非水溶剂中将式(II)的酸氯与芳香胺(III)反应，其中，在没有辅助碱的情况下，a) 首先加入酸氯(II)，b) 建立0至700毫巴的压力，c) 以近似化学计量的量滴定芳香胺(III)，d) 分离所得产物的价值。
• MULTIPURPOSE BIOLOGICAL COMPOSITIONS
  申请人：Agrivalle Brasil Industria e Comércio de Produtos Agrícolas Ltda

  公开号：EP3954214A1

  公开（公告）日：2022-02-16

  The present patent invention relates to multipurpose biological compositions pertaining to the technical sector of biotechnology for the biological control of phytopathogens, phytonematodes, agricultural pests, inoculating agent, phosphorus solubilization, soil conditioning, biostimulant, reduction of hydric stress in cultivated plants and bioremediation in cultivatable or other areas, and more specifically relates to compositions containing mixtures of additives and excipients with at least two (2) species from Bacillus or two (2) or more strains of a given species and mutants thereof; at least two (2) representatives of fungi from the orders Hypocreales, Orbiliales, Helotiales and Mucorales or two (2) or more strains of a given species from representatives of the orders and mutants thereof; Bacillus in mixtures with fungi from the orders Hypocreales, Orbiliales, Helotiales and Mucorales, and combinations between some or all of said fungi (in colony-forming units, CFU) with or without pesticides (fungicides, insecticides, acaricides, herbicides and nematicides), essential oils from plants or plant extract with nematicidal effects to control and reduce damage caused by phytonematodes, with fungicidal effects to control and reduce damage caused by phytopathogens, with insecticidal action to control and reduce damage caused by insects and mites, with growth-promoting action, soil conditioner, biostimulants, to mitigate hydric stress in cultivated plants and bioremediation in cultivatable or other areas, this composition enhances the efficiency in the training of the cultivated plants by using mechanisms with different and complementary actions of the compositions of microorganisms and noteworthy chemical or biological active ingredients.

  本专利发明涉及生物技术领域的多用途生物组合物，用于植物病原体、植物线虫、农业害虫的生物防治、接种剂、磷增溶、土壤改良、生物刺激剂、更具体地说，涉及含有至少两（2）种芽孢杆菌的添加剂和赋形剂混合物或两 （2）个或更多给定种类的菌株及其突变体的组合物；至少两（2）种真菌，分别来自下真菌纲（Hypocreales）、奥氏真菌纲（Orbiliales）、螺旋真菌纲（Helotiales）和粘菌纲（Mucorales），或者两（2）种或更多来自上述真菌纲代表菌种的特定菌株及其突变体；芽孢杆菌（Bacillus）与下真菌纲（Hypocreales）、奥氏真菌纲（Orbiliales）、螺旋真菌纲（Helotiales）和粘菌纲（Mucorales）真菌的混合物，以及部分或全部上述真菌（以菌落形成单位 CFU 计）与或不与杀虫剂（杀真菌剂、杀虫剂、杀螨剂、除草剂、除臭剂）的混合物、杀真菌剂、杀虫剂、杀螨剂、除草剂和杀线虫剂）、具有杀线虫作用的植物精油或植物提取物，以控制和减少植物线虫造成的损害；具有杀真菌作用，以控制和减少植物病原体造成的损害、具有杀虫作用，可控制和减少昆虫和螨虫造成的损害；具有生长促进作用、土壤改良剂、生物刺激剂，可减轻栽培植物的水分胁迫，并对可栽培区域或其他区域进行生物修复，这种组合物通过利用微生物组合物和值得注意的化学或生物活性成分的不同和互补作用机制，提高了栽培植物的培育效率。
• INSECT REPELLENT
  申请人：FMC Corporation

  公开号：EP4046491A1

  公开（公告）日：2022-08-24

  In one aspect, this invention relates to pest repellent compositions comprising a fatty acid and an anthranilate ester. In another aspect, this invention relates to a method of repelling pests employing such composition. In another aspect, this invention relates to products formulated from such composition.

  一方面，本发明涉及由脂肪酸和蒽酸酯组成的驱虫组合物。另一方面，本发明涉及使用这种组合物驱除害虫的方法。另一方面，本发明涉及用这种组合物配制的产品。
• Compositions and methods for use of insecticide with Bacillus sp. D747
  申请人：FMC Corporation

  公开号：US10080368B2

  公开（公告）日：2018-09-25

  Compositions and methods are provided for benefiting plant growth. In particular aspects, the compositions contain a biologically pure culture of Bacillus sp. D747 strain (deposited as FERM BP-8234) and an insecticide in a formulation suitable for dissolution in a liquid fertilizer.

  提供了有利于植物生长的组合物和方法。在特定方面，这些组合物含有生物纯培养的芽孢杆菌 D747 菌株（存为 FERM BP-8234）和杀虫剂，其配方适合溶解在液体肥料中。
• Microbial compositions and methods of use for benefiting plant growth and treating plant disease
  申请人：FMC Corporation

  公开号：US10375964B2

  公开（公告）日：2019-08-13

  Compositions and methods are provided for a combination of a new strain of Bacillus amyloliquefaciens RTI301 and a new strain of Bacillus subtilis RTI477, the combination having growth promoting activity and activity against plant pathogens. The compositions containing the RTI301 and RTI477 strains are useful for benefiting plant growth and/or conferring protection against a pathogenic infection when applied to plant roots, seeds, callus tissue, grafts, and cuttings. Synergistic results are observed for the combination of the strains, and the combination of strains is useful to increase yield in crops including soybean and corn. The compositions containing the combination of strains can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, and fertilizers.

  本发明提供了淀粉芽孢杆菌新菌株 RTI301 和枯草芽孢杆菌新菌株 RTI477 的组合物和方法，该组合物具有促进生长的活性和抗植物病原体的活性。含有 RTI301 和 RTI477 菌株的组合物用于植物根部、种子、胼胝组织、移植物和插条时，可促进植物生长和/或保护植物免受病原体感染。菌株组合具有协同增效作用，菌株组合可提高大豆和玉米等作物的产量。含有菌株组合的组合物可单独施用，也可与其他微生物、生物或化学杀虫剂、杀真菌剂、杀线虫剂、杀菌剂、除草剂、植物提取物、植物生长调节剂和肥料一起施用。