4-methoxy-2-[2-(5-methyl[1,2,4]triazolo[1,5-a]pyridin-2-yl)ethyl]quinoline | 1445745-77-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-methoxy-2-[2-(5-methyl[1,2,4]triazolo[1,5-a]pyridin-2-yl)ethyl]quinoline
• 英文别名: US9216986, 4-Methoxy-2-[2-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-ethyl]-quinoline；4-methoxy-2-[2-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)ethyl]quinoline
• CAS: 1445745-77-6
• 化学式: C₁₉H₁₈N₄O
• 分子量: 318.378
• InChiKey: VKIBGGWUVCBSQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  52.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• New compounds
  申请人：Novartis Tiergesundheit AG

  公开号：EP2957557A1

  公开（公告）日：2015-12-23

  The present invention relates to a new compound of formula wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates.

  本发明涉及一种新的化合物，其化学式为（I），其中变量的含义如权利要求书所示；或其对映体或盐。公式（I）的化合物在控制寄生虫，特别是内寄生虫在脊椎动物体内和体外方面具有用途。
• NEW SULFONYLAMINOBENZAMIDE COMPOUNDS
  申请人：NOVARTIS TIERGESUNDHEIT AG

  公开号：US20160221937A1

  公开（公告）日：2016-08-04

  The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates.

  本发明涉及一种新的化合物(I)的公式，其中变量的含义如权利要求书中所示；或其对映体或盐。公式(I)的化合物在控制寄生虫，特别是脊椎动物体内和体外的内寄生虫方面具有用途。
• Quinoline derivatives as PDE10A enzyme inhibitors
  申请人：H. Lundbeck A/S

  公开号：US20150376186A1

  公开（公告）日：2015-12-31

  The present invention provides quinoline derivatives of formula I that are PDE10A enzyme inhibitors, and as such are useful to treat neurodegenerative and psychiatric disorders. Especially, the invention provides compounds that are highly selective for PDE10 over other PDE subtypes. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.

  本发明提供了式I的喹啉衍生物，它们是PDE10A酶抑制剂，因此可用于治疗神经退行性和精神障碍。特别地，本发明提供了高度选择性作用于PDE10而非其他PDE亚型的化合物。本发明还提供了包含本发明化合物的制药组合物和使用本发明化合物治疗疾病的方法。
• Quinoline Derivatives as PDE10A Enzyme Inhibitors
  申请人：H. Lundbeck A/S

  公开号：US20160303120A1

  公开（公告）日：2016-10-20

  The present invention provides quinoline derivatives of formula I that are PDE10A enzyme inhibitors, and as such are useful to treat neurodegenerative and psychiatric disorders. Especially, the invention provides compounds that are highly selective for PDE10A over other PDE subtypes. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.
• US9216986B1
  申请人：——

  公开号：US9216986B1

  公开（公告）日：2015-12-22