2-(Difluoromethoxy)-4,6-dimethylpyridine | 1214379-04-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(Difluoromethoxy)-4,6-dimethylpyridine
• CAS: 1214379-04-0
• 化学式: C₈H₉F₂NO
• 分子量: 173.16
• InChiKey: IAGKOJCNBBXNPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] PYRAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS DE PYRAZOLE
  申请人：HUA MEDICINE (SHANGHAI) LTD

  公开号：WO2017117708A1

  公开（公告）日：2017-07-13

  Provided herein are compounds of the formula I: as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment or prevention of mGluR5 mediated disorders, such as acute and/or chronic neurological disorders, cognitive disorders and memory deficits, as well as acute and chronic pain.

  本文提供了公式I的化合物，以及其药学上可接受的盐，其中取代基如规范中所披露的那样。这些化合物及含有它们的药物组合物对于治疗或预防mGluR5介导的疾病非常有用，例如急性和/或慢性神经系统疾病、认知障碍和记忆缺陷，以及急性和慢性疼痛。
• Pyrrolidinones and a process to prepare them
  申请人：FMC Corporation

  公开号：US10875838B2

  公开（公告）日：2020-12-29

  This application is directed to a compound of Formula II Also disclosed is a process for preparing a compound of Formula II comprising using the compounds of Formulae IV and V Also disclosed is a method for preparing a compound of Formula I comprising contacting a compound of Formula II with a compound of a compound of Formula VI wherein A1, A2 A3, R1, R2, R3a, R3b, R4, B1, B2 and B3, are as defined in the disclosure.

  本申请涉及一种式 II 的化合物 还公开了一种制备式 II 的化合物的工艺，包括使用式 IV 和 V 的化合物 还公开了一种制备式 I 的化合物的方法，包括将式 II 的化合物与式 VI 的化合物接触 其中 A1、A2 A3、R1、R2、R3a、R3b、R4、B1、B2 和 B3 如公开中定义。
• PYRROLIDINONES AND A PROCESS TO PREPARE THEM
  申请人：FMC Corporation

  公开号：US20210107890A1

  公开（公告）日：2021-04-15

  This application is directed to a compound of Formula II Also disclosed is a process for preparing a compound of Formula II comprising using the compounds of Formulae IV and V Also disclosed is a method for preparing a compound of Formula I comprising contacting a compound of Formula II with a compound of a compound of Formula VI wherein A 1 , A 2 A 3 , R 1 , R 2 , R 3a , R 3b , R 4 , B 1 , B 2 and B 3 , are as defined in the disclosure.