N-(3,5-dichloropyridin-4-yl)-N'-[2-ethyl-6-(2'-hydroxy-5'-methylbiphenyl-3-yl)-3-oxo-2,3-dihydropyridazin-4-yl]urea | 1229437-77-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,5-dichloropyridin-4-yl)-N'-[2-ethyl-6-(2'-hydroxy-5'-methylbiphenyl-3-yl)-3-oxo-2,3-dihydropyridazin-4-yl]urea
• 英文别名: 1-(3,5-Dichloropyridin-4-yl)-3-[2-ethyl-6-[3-(2-hydroxy-5-methylphenyl)phenyl]-3-oxopyridazin-4-yl]urea
• CAS: 1229437-77-7
• 化学式: C₂₅H₂₁Cl₂N₅O₃
• 分子量: 510.379
• InChiKey: YRDWAGIDARRDSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
  申请人：Almirall, S.A.

  公开号：EP2196465A1

  公开（公告）日：2010-06-16

  New (3-oxo)pyridazin-4-ylurea derivatives having the chemcial structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the phosphodiesterase IV (PDE4).

  揭示了具有化学结构式（I）的新（3-氧代）吡啶并嘧啶-4-基脲衍生物；以及它们的制备方法，包含它们的药物组合物以及它们作为磷酸二酯酶IV（PDE4）抑制剂在治疗中的用途。
• [EN] (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS<br/>[FR] DÉRIVÉS DE (3-OXO)PYRIDIN-4-YLURÉE EN TANT QU'INHIBITEURS DE LA PDE4
  申请人：ALMIRALL SA

  公开号：WO2010069504A1

  公开（公告）日：2010-06-24

  New (3-oxo)pyridazin-4-ylurea derivatives having the chemcial structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the phosphodiesterase IV (PDE4).