methyl 2-(2-(2-cyclopropoxyphenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoate | 1119091-29-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2-(2-(2-cyclopropoxyphenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoate
• 英文别名: Methyl 5-cyclopropyl-2-[[2-(2-cyclopropyloxyphenyl)pyrimidin-5-yl]amino]benzoate
• CAS: 1119091-29-0
• 化学式: C₂₄H₂₃N₃O₃
• 分子量: 401.465
• InChiKey: LOIMVRASLCAODN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  73.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] AZABIPHENYLAMINOBENZOIC ACID DERIVATIVES AS DHODH INHIBITORS<br/>[FR] DÉRIVÉS D'ACIDE AZABIPHÉNYLAMINOBENZOÏQUE COMME INHIBITEURS DE LA DHODH
  申请人：ALMIRALL LAB

  公开号：WO2009021696A1

  公开（公告）日：2009-02-19

  New azabiphenylaminobenzoic acid derivatives having the chemcial structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the dehydroorotate dihydrogenase (DHODH).

  揭示了具有化学结构式(I)的新的阿扎比苯胺基苯甲酸衍生物；以及它们的制备过程、包含它们的药物组合物以及它们在治疗中作为脱氢乳酸脱氢酶（DHODH）抑制剂的用途。
• Amino derivatives for the treatment of proliferative skin disorders
  申请人：Almirall, S.A.

  公开号：EP2444088A1

  公开（公告）日：2012-04-25

  Compositions comprising specific amino derivatives for their use in treating proliferative skin diseases or disorders and the use of specific amino derivatives in such a treatment is disclosed.

  本发明公开了包含特定氨基衍生物的组合物，用于治疗增生性皮肤疾病或疾病的用途，并公开了在此类治疗中使用特定氨基衍生物的方法。
• AZABIPHENYLAMINOBENZOIC ACID DERIVATIVES AS DHODH INHIBITORS
  申请人：Castro Palomino Laria Julio Cesar

  公开号：US20110212945A1

  公开（公告）日：2011-09-01

  The present disclosure relates to new azabiphenylaminobenzoic acid derivatives of formula (I); as well as processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy as inhibitors of the dehydroorotate dihydrogenase (DHODH).

  本公开涉及新的式(I)的氮杂联苯氨基苯甲酸衍生物，以及它们的制备方法，包括它们的制药组合物，以及它们在治疗中作为脱氢鸟嘌呤二氢酶（DHODH）抑制剂的用途。
• Combinations comprising DHODH inhibitors and COX inhibitors
  申请人：Almirall, S.A.

  公开号：EP2444086A1

  公开（公告）日：2012-04-25

  Combinations comprising (a) DHODH inhibitors and (b) COX inhibitors and their use in treating skin diseases or disorders are disclosed.

  本研究公开了由(a) DHODH 抑制剂和(b) COX 抑制剂组成的组合物及其在治疗皮肤疾病或失调中的用途。
• US8536165B2
  申请人：——

  公开号：US8536165B2

  公开（公告）日：2013-09-17