提纯专利兰紫 | 68238-36-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 提纯专利兰紫
• 中文别名: 异硫蓝
• CAS: 68238-36-8
• 化学式: C27H32N2NaO6S2
• 分子量: 567.7
• InChiKey: AVZOEHZTSPLXBS-UHFFFAOYSA-N

物化性质

• 溶解度：
  溶于二甲基亚砜
• 颜色/状态：
  Blue-green liquid
• 蒸汽压力：
  1.87X10-36 mm Hg at 25 °C (est)
• 亨利常数：
  Henry's Law constant = 6.54X10-28 atm-cu m/mol at 25 °C (est)
• LogP：
  log Koc = -2.34 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  3.72
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  135
• 氢给体数：
  1
• 氢受体数：
  7

ADMET

毒理性

• 解毒与急救

/SRP:/ 立即急救：确保已经进行了充分的中和。如果患者停止呼吸，请开始人工呼吸，最好使用需求阀复苏器、球囊阀面罩设备或口袋面罩，按训练进行操作。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果患者呕吐，让患者向前倾或将其置于左侧（如果可能，头部向下），以保持呼吸道畅通，防止误吸。保持患者安静，维持正常体温。寻求医疗帮助。 /毒物A和B/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 基本治疗：建立专利气道（如有需要，使用口咽或鼻咽气道）。如有必要，进行吸痰。观察呼吸不足的迹象，如有需要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……。监测休克，如有必要，进行治疗……。预期癫痫发作，如有必要，进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用0.9%的生理盐水（NS）持续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能够吞咽、有强烈的干呕反射且不流口水，则用温水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。在去污后，用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 高级治疗：对于无意识、严重肺水肿或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。考虑使用药物治疗肺水肿……。对于严重的支气管痉挛，考虑给予β激动剂，如沙丁胺醇……。监测心率和必要时治疗心律失常……。开始静脉输注D5W /SRP: "保持开放"，最小流量/。如果出现低血容量的迹象，使用0.9%的生理盐水（NS）或乳酸林格氏液。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象……。使用地西泮或劳拉西泮治疗癫痫……。使用丙美卡因氢氯化物协助眼部冲洗……。 /Poisons A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

/HUMAN EXPOSURE STUDIES/ 某些重要染料已知会导致脉搏血氧饱和度（Spo2）降低。作者研究了异硫蓝（IB）对Spo2的影响。研究了33名年龄在34-81岁之间的乳腺癌手术患者。外科医生将5 mL（50 mg）的IB注射到肿瘤周围组织中。使用脉搏血氧计连续记录注射IB后130分钟内的Spo2值。使用FriedMAn重复测量等级分析方法分析了基线Spo2以及5、10、20、30、40、50和60分钟时的值。在5、10、20、30、40、50和60分钟时，Spo2值与基线值有显著差异（p < 0.05）。在典型患者中，可以在注射IB后25分钟预期最大Spo2降低3%。在肿瘤周围给药IB，50 mg后，Spo2会出现显著干扰。

/HUMAN EXPOSURE STUDIES/ Certain vital dyes are known to cause pulse oximetry (Spo2) desaturation. The authors studied the effect of isosulfan blue (IB) on Spo2. Thirty-three women, aged 34-81 yr, who were undergoing surgery for breast cancer were studied. IB, 5 mL (50 mg), was injected intraparenchymally around the tumor area by the surgeon. A pulse oximeter was used to continuously record Spo2 values up to 130 min after IB injection. Friedman repeated-measures analysis of ranks was used to analyze the baseline Spo2 and values at 5, 10, 20, 30, 40, 50, and 60 min. Spo2 values were significantly different from baseline values at 5, 10, 20, 30, 40, 50, and 60 min (p < 0.05). In a typical patient, a maximum Spo2 decrease of 3% can be anticipated 25 min after injection of IB. After peritumoral administration of IB, 50 mg, a significant interference with Spo2 will occur.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

人类暴露研究/两名患有乳腺癌的女性患者被评估……在哨兵淋巴结活检期间疑似出现术中过敏性休克后，她们接受了1%的异硫氰蓝以可视化淋巴管。在第一个病例中，患者出现低血压和低氧血症，需要插管。在第二个病例中，患者出现持续性低血压。两位患者均无后遗症恢复。对患者进行了/检查/，并进行了异硫氰蓝的皮肤测试，以及患者在麻醉期间接受的其他药物的皮肤测试。在这两个病例中，患者对异硫氰蓝的皮肤测试呈阳性。没有任何其他用于皮肤测试的药物对患者产生阳性皮肤测试。对9名对照受试者进行了异硫氰蓝皮肤测试，所有对照受试者的皮肤测试均为阴性。异硫氰蓝可能是过敏性反应的原因，这似乎是通过阳性皮肤测试证实的免疫球蛋白E介导的事件。

/HUMAN EXPOSURE STUDIES/ Two female patients with breast cancer were evaluated ... after suspected intraoperative anaphylactic episodes during sentinel lymph node biopsies in which they had received isosulfan blue 1% for the purpose of visualization of the lymph vessels. In the first case, the patient suffered hypotension and hypoxia requiring intubation. In the second case, the patient suffered prolonged hypotension. Both patients recovered without sequelae. The patients were /examined/ and skin tests were performed to isosulfan blue in addition to other agents the patients had received during anesthesia. In both cases, the patients demonstrated positive skin tests to isosulfan blue. Neither patient had positive skin tests to any other agent used for skin testing. Isosulfan blue skin tests were performed in nine control subjects and all skin tests in the control subjects were negative. Isosulfan blue may be a cause of anaphylactic reactions and this seems to be an immunoglobulin E-mediated event as confirmed by positive skin tests.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

皮下注射后，1%的异硫蓝注射液会与血清蛋白结合，并被淋巴管吸收。因此，淋巴管会被蓝色染料勾勒出来。

Following subcutaneous administration, isosulfan blue injection 1% binds to serum proteins and is picked up by the lymphatic vessels. Thus, the lymphatic vessels are delineated by the blue dye.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

目前尚不清楚这种药物是否会被分泌入人乳中。

It is not known whether this drug is excreted in human milk.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

皮下注射的1%异硫蓝注射剂在24小时内，人体中有高达10%的剂量未改变地通过尿液排出。

Up to 10% of the subcutaneously administered dose of isosulfan blue injection 1% is excreted unchanged in the urine in 24 hours in humans.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险性防范说明：
  P261,P264,P271,P280,P302+P352,P304+P340,P305+P351+P338,P312,P321,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H315,H319,H335

制备方法与用途

生物活性

Isosulfan blue 是一种用于淋巴管造影中淋巴管识别的蓝色染料。Isosulfan blue 用于乳腺癌前哨淋巴结活检。Isosulfan blue 在乳腺癌手术中可能有过敏反应。

体外研究

Isosulfan blue can rapidly uptake into lymph tissue with little diffusion to other surrounding tissues.