Minnelide free acid | 1254885-39-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: Minnelide free acid
• 英文别名: [(1S,2S,4S,5S,7S,8R,9R,11S,13S)-1-methyl-17-oxo-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-8-yl]oxymethyl dihydrogen phosphate
• CAS: 1254885-39-6
• 化学式: C₂₁H₂₇O₁₀P
• 分子量: 470.4
• InChiKey: QROUIGQWVUTWFM-RWBWCDHPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  140
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• TRIPTOLIDE PRODRUGS
  申请人：REGENTS OF THE UNIVERSITY OF MINNESOTA

  公开号：US20140107077A1

  公开（公告）日：2014-04-17

  The invention provides compounds of formula I: or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the compounds of formula I.

  本发明提供了公式I的化合物：或其盐。本发明还提供包括公式I化合物的制药组合物，制备公式I化合物的方法，制备公式I化合物有用的中间体以及使用公式I化合物的治疗方法。
• THERAPEUTICAL COMPOSITIONS FOR USE IN THE TREATMENT OF NON-MALIGNANT CONDITIONS ASSOCIATED WITH PHOSPHATIDYLINOSITOL-3-KINASE ACTIVATION: OVERGROWTH SPECTRUM, CUTANEOUS CAPILLARY MALFORMATIONS AND SEBORRHEIC KERATOSES
  申请人：UNIVERSITÉ DE BOURGOGNE

  公开号：US20210393570A1

  公开（公告）日：2021-12-23

  A method of treatment of PIK3CA Related Overgrowth Spectrum, cutaneous capillary malformations, and seborrheic kératoses by administration, to a patient in need, of a pharmaceutical composition including an inhibitor of heat-shock factor 1 (HSF1), wherein the inhibitor of heat-shock factor 1 is selected among one or more of Triptolide, Minnelide, Kribb11, Quercetin, QC-12, Quercetin derivatives, KNK437, Stresgenin B, Emunin, NZ28, Cantharidin, Rocaglamide A, Rohinitib, Rohinitib-Cantharidin hybrids ligands, Arctigenin, and pharmaceutically acceptable derivatives, salts and solvates thereof.
• US8507552B2
  申请人：——

  公开号：US8507552B2

  公开（公告）日：2013-08-13
• US9150600B2
  申请人：——

  公开号：US9150600B2

  公开（公告）日：2015-10-06
• US9623035B2
  申请人：——

  公开号：US9623035B2

  公开（公告）日：2017-04-18