2-{4-[3-(2,4-dimethoxybenzylamino)-2-hydroxypropoxy]phenyl}-3-(5-methylthiophen-2-yl)acrylic acid methyl ester | 1151808-67-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-{4-[3-(2,4-dimethoxybenzylamino)-2-hydroxypropoxy]phenyl}-3-(5-methylthiophen-2-yl)acrylic acid methyl ester
• 英文别名: Methyl 2-[4-[3-[(2,4-dimethoxyphenyl)methylamino]-2-hydroxypropoxy]phenyl]-3-(5-methylthiophen-2-yl)prop-2-enoate
• CAS: 1151808-67-1
• 化学式: C₂₇H₃₁NO₆S
• 分子量: 497.612
• InChiKey: PPHSAWCGKZVGSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  35
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• STILBENE DERIVATIVES AS PSTAT3/IL-6 INHIBITORS
  申请人：Rajagopal Sridharan

  公开号：US20100298402A1

  公开（公告）日：2010-11-25

  Described are novel compounds of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These novel compounds can inhibit pSTAT3/IL-6 and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, etc.

  描述了公式（I）的新化合物，它们的衍生物、类似物、互变异构体、立体异构体、多型体、水合物、溶剂合物、中间体、药学上可接受的盐、药物组合物、代谢物和前药。这些新化合物可以抑制pSTAT3/IL-6，并且可用作治疗或改善细胞生长相关疾病的药物或缓解剂，如恶性肿瘤、自身免疫疾病、皮肤病、感染、炎症等。
• [EN] STILBENE DERIVATIVES AS PSTAT3/IL-6 INHIBITORS<br/>[FR] DÉRIVÉS DE STILBÈNE EN TANT QU'INHIBITEURS DE PSTAT3/IL-6
  申请人：ORCHID RES LAB LTD

  公开号：WO2009060282A2

  公开（公告）日：2009-05-14

  Described are novel compounds of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These novel compounds can inhibit pSTAT3/IL-6 and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, etc.