1-(1-(5-cyano-2-(3,5-dichlorophenoxy)phenylsulfonyl)piperidin-4-yl)-3-(2-(4-methylpiperazin-1-yl)ethyl)urea phosphate | 1371587-37-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(1-(5-cyano-2-(3,5-dichlorophenoxy)phenylsulfonyl)piperidin-4-yl)-3-(2-(4-methylpiperazin-1-yl)ethyl)urea phosphate
• 英文别名: 1-[1-[5-Cyano-2-(3,5-dichlorophenoxy)phenyl]sulfonylpiperidin-4-yl]-3-[2-(4-methylpiperazin-1-yl)ethyl]urea;phosphoric acid
• CAS: 1371587-37-9
• 化学式: C₂₆H₃₂Cl₂N₆O₄S*H₃O₄P
• 分子量: 693.545
• InChiKey: UOLQDMVOEZRHTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.43
• 重原子数：
  44
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  204
• 氢给体数：
  5
• 氢受体数：
  12

文献信息

• SALTS OF ARYLSULFONAMIDE CCR3 ANTAGONISTS
  申请人：LY Tai Wei

  公开号：US20120088769A1

  公开（公告）日：2012-04-12

  Provided herein are arylsulfonamide salts, e.g., a salt of a compound of Formula I, which are useful for modulating CCR3 activity, and their pharmaceutical compositions. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disorder, disease, or condition.