N-[(5-cyclopropyl-6-methoxypyridin-2-yl)methyl]-5'-methyl-5-(1,3-thiazol-2-yl)-2,3'-bipyridine-4-carboxamide | 1224846-03-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-[(5-cyclopropyl-6-methoxypyridin-2-yl)methyl]-5'-methyl-5-(1,3-thiazol-2-yl)-2,3'-bipyridine-4-carboxamide
• 英文别名: N-[(5-Cyclopropyl-6-methoxy-2-pyridinyl)methyl]-5a(2)-methyl-5-(2-thiazolyl)[2,3a(2)-bipyridine]-4-carboxamide；N-[(5-cyclopropyl-6-methoxypyridin-2-yl)methyl]-2-(5-methylpyridin-3-yl)-5-(1,3-thiazol-2-yl)pyridine-4-carboxamide
• CAS: 1224846-03-0
• 化学式: C₂₅H₂₃N₅O₂S
• 分子量: 457.556
• InChiKey: IVIBTAHBQDWLMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] ISONICOTINAMIDE OREXIN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES D'ISONICOTINAMIDE DES RÉCEPTEURS DE L'OREXINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2010051236A1

  公开（公告）日：2010-05-06

  The present invention is directed to isonicotinamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及异烟酰胺化合物，这些化合物是促进睡眠的受体拮抗剂，可用于治疗或预防涉及促进睡眠的神经和精神障碍和疾病。该发明还涉及包含这些化合物的药物组合物，以及在预防或治疗涉及促进睡眠的这类疾病中使用这些化合物和组合物。
• ISONICOTINAMIDE OREXIN RECEPTOR ANTAGONISTS
  申请人：Bergman Jeffrey M.

  公开号：US20110201591A1

  公开（公告）日：2011-08-18

  The present invention is directed to isonicotinamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及异烟酰胺化合物，其是促进睡眠的荷尔蒙受体拮抗剂，可用于治疗或预防神经系统和精神疾病，以及涉及荷尔蒙受体的疾病。本发明还涉及包含这些化合物的制药组合物和使用这些化合物和组合物预防或治疗涉及荷尔蒙受体的疾病。
• US8592457B2
  申请人：——

  公开号：US8592457B2

  公开（公告）日：2013-11-26