1-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-{[(2R,3S)-2-({[3-({[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]amino}sulfonyl)benzoyl]amino}methyl)-4-oxo-1-sulfoazetidin-3-yl]amino}-2-oxoethylidene]amino}oxy)cyclobutanecarboxylic acid | 1380112-08-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 1-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-{[(2R,3S)-2-({[3-({[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methyl]amino}sulfonyl)benzoyl]amino}methyl)-4-oxo-1-sulfoazetidin-3-yl]amino}-2-oxoethylidene]amino}oxy)cyclobutanecarboxylic acid
• 英文别名: 1-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2R,3S)-2-[[[3-[(1,5-dihydroxy-4-oxopyridin-2-yl)methylsulfamoyl]benzoyl]amino]methyl]-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxycyclobutane-1-carboxylic acid
• CAS: 1380112-08-2
• 化学式: C₂₇H₂₈N₈O₁₄S₃
• 分子量: 784.763
• InChiKey: LJYLDAXOEZVCBH-IOQCMWPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  52
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  383
• 氢给体数：
  8
• 氢受体数：
  20

文献信息

• [EN] MONOBACTAMS<br/>[FR] MONOBACTAMES
  申请人：PFIZER

  公开号：WO2012073138A1

  公开（公告）日：2012-06-07

  The present invention is directed to a new class of monobactam derivatives and their use for treating bacterial infections.

  本发明涉及一类新的单环内酰胺衍生物及其用于治疗细菌感染的用途。
• MONOBACTAMS
  申请人：Pfizer Inc.

  公开号：EP2646436B1

  公开（公告）日：2015-05-27
• SKIN CARE COMPOSITION WITH INDICATING FUNCTION AND METHOD OF USING THE SAME
  申请人：Yang Pei-Fen

  公开号：US20120301406A1

  公开（公告）日：2012-11-29

  A skin care composition with indicating function including a skin care component, a pH indicator and a buffer solution is provided. The skin care composition has a pH value less than or equal to 8. A method of using the skin care composition includes the following. The skin care composition is applied on a skin surface. After the skin care composition is applied on the skin surface for a period of time, the color of the skin care composition changes. When the color of the skin care composition changes, the skin care composition is removed from the skin surface.
• Monobactams
  申请人：Pfizer Inc.

  公开号：US20150148326A1

  公开（公告）日：2015-05-28

  The present invention is directed to a new class of monobactam derivatives and their use for treating bacterial infections.