N-氰基异烟酰胺 | 325801-73-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: N-氰基异烟酰胺
• 英文名称: N-Cyano-4-pyridinecarboxamide
• 英文别名: N-cyanopyridine-4-carboxamide
• CAS: 325801-73-8
• 化学式: C₇H₅N₃O
• 分子量: 147.13
• InChiKey: BIAGWQYHUNVQCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Pyrrol derivatives with antibacterial activity
  申请人：Green Morenike Oluyinka

  公开号：US20060223801A1

  公开（公告）日：2006-10-05

  Compounds of Formula (1) and their pharmaceutically acceptable salts are described: Formula (1) Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

  本文描述了化学式（1）的化合物及其药用可接受的盐：化学式（1）。同时描述了其制备方法、含有它们的药物组合物、作为药物的用途以及在治疗细菌感染方面的应用。
• Beta-lactam compounds, process for the preparation thereof and intermediate products for the preparation thereof
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP0048954A2

  公开（公告）日：1982-04-07

  There are disclosed a compound having the following formula: in which R' denotes an aromatic group; Z represents a group (wherein R' denotes hydrogen, a salt forming cation or a protective group for carboxylic acid, and R' denotes hydrogen or a residue of a nucleophilic compound); and X' and X2 each represent hydrogen or a halogen atom, provided that both X' and X2 cannot represent hydrogen at the same time; processes for preparing the same; and an intermediate compound useful for preparing the same. The above mentioned compound has a broad antibacterial spectrum and shows strong antibacterial activities against not only gram-positive bacteria but also the gram-negative bacteria, particularly the resistive gram-negative bacteria.

  公开了一种具有下式的化合物：其中 R'表示芳香基团；Z 表示一个基团（其中 R'表示氢、形成盐的阳离子或羧酸的保护基团，R'表示氢或亲核化合物的残基）；X'和 X2 各自表示氢或卤素原子，但 X'和 X2 不能同时表示氢；制备上述化合物的工艺；以及制备上述化合物的中间化合物。 上述化合物具有广阔的抗菌谱，不仅对革兰氏阳性菌，而且对革兰氏阴性菌，特别是抵抗性革兰氏阴性菌都有很强的抗菌活性。
• Beta-lactam compounds and process for the preparation thereof
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP0082498A2

  公开（公告）日：1983-06-29

  There are disclosed a compound having the following formula: in which R1 denotes a substituted or unsubstituted thiazolyl radical, a substituted or unsubstituted thiazolylmercapto radical or a substituted or unsubstituted phenyl radical; R2 denotes a halogen atom, a cyano radical, a carbamoyl radical, a lower-alkylmercapto radical or an 0-lower-alkylcarboxyimidoyl radical; and Y represents a group (wherein R3 denotes hydrogen, a salt forming cation or a protective group for a carboxylic acid, and R denotes hydrogen or a residue of a nucleophilic compound); process for preparing the same; and an intermediate compound useful for preparing the same. The above mentioned compound has a broad antibacterial spectrum and shows strong antibacterial activities against not only gram-positive bacteria but also gram-negative bacteria, particularly the resistive gram-negative becteria.

  公开了具有下式的化合物： 其中 R1 表示取代或未取代的噻唑基、取代或未取代的噻唑巯基或取代或未取代的苯基； R2 表示卤素原子、氰基、氨基甲酰基、低级烷基巯基或 0-低级烷基羧基亚酰胺酰基； Y 代表一个基团 (其中 R3 表示氢、形成盐的阳离子或羧酸的保护基团，R 表示氢或亲核化合物的残基）；制备上述化合物的工艺；以及用于制备上述化合物的中间体化合物。 上述化合物具有广泛的抗菌谱，不仅对革兰氏阳性菌，而且对革兰氏阴性菌，特别是抗性革兰氏阴性菌都有很强的抗菌活性。
• New substituted cephalosporin sulfones as antiinflammatory and antidegenerative agents, pharmaceutical compositions containing the same and processes for making them
  申请人：Merck & Co., Inc.

  公开号：EP0124081A2

  公开（公告）日：1984-11-07

  New substituted cephalosporin sulfones are disclosed having the structural formula: wherein M is, e.g., trifluoromethyl, chloro or fluoro or-COOH; R1 is, e.g., hydrogen, hydroxy, mercapto, substituted oxy, substituted thio, hydrocarbyl or substituted hydrocarbyl group; B is OB1 or NB2B3 wherein B1 and B2 independently are, e.g., straight or branched chain alkyl having from 1 to 20 carbon atoms, aryl having from 6 to 10 carbon atoms or cycloalkyl having from 3 to 8 carbon atoms; B3 is B1 or hydrogen; and Q is, e.g., hydrogen, C1-6alkyl, halo C1-6alkyl or hydroxy C1-6alkyl. Those compounds are potent elastase inhibitors and thereby useful antiinflammatory/antidegenerative agents. A process for preparing those compounds is also disclosed.

  公开了具有以下结构式的新取代头孢砜： 其中 M 是例如三氟甲基、氯或氟或-COOH； R1 是例如氢、羟基、巯基、取代氧基、取代硫代、烃基或取代烃基； B 是 OB1 或 NB2B3 其中 B1 和 B2 独立地是例如具有 1 至 20 个碳原子的直链或支链烷基、具有 6 至 10 个碳原子的芳基或环基、B3 是 B1 或氢；Q 是氢、C1-6 烷基、卤代 C1-6 烷基或羟基 C1-6 烷基。这些化合物是有效的弹性蛋白酶抑制剂，因此是有用的抗炎/抗变性剂。还公开了制备这些化合物的工艺。
• Tetrazolyl derivatives of beta-lactams useful as elastase inhibitors
  申请人：Merck & Co., Inc.

  公开号：EP0207447A2

  公开（公告）日：1987-01-07

  Tetrazolyl derivatives of β-lactams are found to be potent elsstase inhibitors and thereby useful anti-inflammatory/antidegenerative agents. Those compounds have the structural formula: wherein T is or wherein n is an integer of 0 to 2; M is, e.g., trifluoromethyl; chloro or fluoro; or -CH2A wherein A represents: (a) Ra-CO-O-; (b) R.HN-CO-O-; (c) RaO-CO-CH2NH-CO-O-; or (d) Ra-S-; R' is, e.g., (1) C1-6alkyl; (2) hydroxy; (3) ORa where R. is (a) C1-6alkyl; (b) -C6H5; (c) -CN2C6H5; (d) -CH2CH2C6N5; (e) , where Rh represents hydrogen, C1-6alkyl, phenyl, benzyl, or C1-6alkylamino; or (4) fluoro or chloro; (5) halo; (6) -SO2Rh; (7) phenyl; or (8) haloC1-6alkyl-CO-NH-; R2 is H; -O-C1-6 alkyl; halo; or C1-6 alkyl; Q' and Q2 independently are, e.g., (1) hydrogen; (2) methyl, ethyl or i-or n-propyl; (3) methylene; (4) phenylthiomethyl or phenyl sulfonylmethyl; (5) benzyl of formula wherein X, and X2 independently are H, OCH3, -COOH, C1- 6alkyl, -COOC1-6-alkyl, -CH2COOH, or CH2COOC1-6-alkyl; or (6) -CH2-CO-ORh; and R is Ra.

  发现β-内酰胺的四唑基衍生物是强效的elsstase抑制剂，因此是有用的抗炎/抗退行性药物。 这些化合物的结构式如下 其中 T 是 或 其中 n 为 0 至 2 的整数；M 为三氟甲基；氯或氟；或 - A，其中 A 代表： (a) Ra-CO-O-； (b) R.HN-CO-O-； (c) RaO-CO- NH-CO-O-；或 (d) Ra-S-； R'是，例如 (1) C1-6 烷基 (2) 羟基 (3) ORa，其中 R. 是 (a) C1-6 烷基 (b) -C6H5 (c) -CN2 (d) - C6N5 (e) 其中 Rh 代表氢、C1-6烷基、苯基、苄基或 C1-6 烷基氨基；或 (4) 氟或氯 (5) 卤代 (6) -SO2Rh (7) 苯基；或 (8) 卤代 C1-6 烷基-CO-NH-； R2 是 H；-O-C1-6 烷基；卤代；或 C1-6 烷基； Q' 和 Q2 独立地是，例如 (1) 氢 (2) 甲基、乙基或 i 或 n-丙基 (3) 亚甲基 (4) 苯硫基甲基或苯磺酰甲基 (5) 式中的苄基 其中 X 和 X2 独立地为 H、OCH3、-COOH、C1-6-烷基、-COOC1-6-烷基、- COOH 或 COOC1-6-烷基；或 (6) -CH2-CO-ORh；且 R 为 Ra。