1-Methyl-1,2,3,6-tetrahydro-4-pyridinessigsaeure-dimethylamid | 13069-16-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Methyl-1,2,3,6-tetrahydro-4-pyridinessigsaeure-dimethylamid
• 英文别名: N,N-dimethyl-2-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)acetamide
• CAS: 13069-16-4
• 化学式: C₁₀H₁₈N₂O
• 分子量: 182.266
• InChiKey: CWIOCQHVZPUDTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Pyrrolopyrimidine and Pyrrolopyridine Derivatives Substituted with Tetrahydropyridine as Crf Antagonists
  申请人：Nakazato Atsuro

  公开号：US20070293670A1

  公开（公告）日：2007-12-20

  [PROBLEM TO BE SOLVED]An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc. [SOLUTION]A pyrrolopyrimidine or pyrrolopyridine derivative substituted with tetrahydropyridine represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

  【需要解决的问题】本发明的目的是提供一种CRF受体拮抗剂，作为治疗或预防CRF参与的疾病的药物，例如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃肠疾病、药物依赖、脑梗死、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合症、睡眠障碍、癫痫、皮炎、精神分裂症、疼痛等。 【解决方案】以下式[I]所表示的以四氢吡啶取代的吡咯吡咯或吡咯吡啶衍生物具有高亲和力，可用于治疗CRF参与的疾病。