(R)-N-(benzo[d]thiazol-2-yl)-4-[5-(2,3-dihydroxypropyl)-3-fluoropyridin-2-yl]benzamide | 1422359-73-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (R)-N-(benzo[d]thiazol-2-yl)-4-[5-(2,3-dihydroxypropyl)-3-fluoropyridin-2-yl]benzamide
• 英文别名: N-(1,3-benzothiazol-2-yl)-4-[5-[(2R)-2,3-dihydroxypropyl]-3-fluoropyridin-2-yl]benzamide
• CAS: 1422359-73-6
• 化学式: C₂₂H₁₈FN₃O₃S
• 分子量: 423.468
• InChiKey: AMBUADZXQKAOQQ-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF<br/>[FR] ANTAGONISTES DU TRPV1 COMPRENANT UN SUBSTITUANT DIHYDROXY ET LEURS UTILISATIONS
  申请人：PURDUE PHARMA LP

  公开号：WO2013021276A1

  公开（公告）日：2013-02-14

  The disclosure relates to Compounds of Formula (I) and pharmaceutically acceptable derivatives thereof wherein Ar1, Ar2, L1 L2, X, R3, R22, and m are as defined herein, compositions comprising an effective amount of a Compound of Formula (I), and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a Compound of Formula (I).

  本公开涉及式(I)的化合物及其药用可接受的衍生物，其中Ar1、Ar2、L1、L2、X、R3、R22和m的定义如本文所述，包括有效量的式(I)化合物的组合物，以及用于治疗或预防疼痛、尿失禁、溃疡、炎症性肠病（IBD）和肠易激综合征（IBS）等疾病的方法，包括向需要的动物施用有效量的式(I)化合物。
• TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF
  申请人：Yu Jianming

  公开号：US20140350056A1

  公开（公告）日：2014-11-27

  The disclosure relates to Compounds of Formula (I): and pharmaceutically acceptable derivatives thereof wherein Ar 1 , Ar 2 , L 1 , L 2 , X, R 3 , R 22 , and m are as defined herein, compositions comprising an effective amount of a Compound of Formula (I), and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a Compound of Formula (I).
• US9394293B2
  申请人：——

  公开号：US9394293B2

  公开（公告）日：2016-07-19
• US9873691B2
  申请人：——

  公开号：US9873691B2

  公开（公告）日：2018-01-23