(2-aminopyridine-N-thio)-1,3-propanediamine | 935255-41-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (2-aminopyridine-N-thio)-1,3-propanediamine
• 英文别名: 1-(3-Aminopropyl)-3-pyridin-2-ylthiourea
• CAS: 935255-41-7
• 化学式: C₉H₁₄N₄S
• 分子量: 210.303
• InChiKey: PSINCJNDCFURMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  95.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-aminopyridine-N-thio)-1,3-propanediamine 、 dihydrogen hexachloroplatinate 以 甲醇 、 水 为溶剂， 生成 [Pt((2-aminopyridine-N-thio)-1,3-propanediamine)2Cl2]
  参考文献：
  名称：

  Platinum (IV) thiohydrazide, thiodiamine and thiohydrazone complexes: A spectral, antibacterial and cytotoxic study

  摘要：

  Some platinum (IV) complexes [Pt(L)(2)Cl-2] [where, L = 2-aminopyridine-N-thiohydrazide (L-1), (2-aminopyridine-N-thio)-1,3-propanediamine (L-2), benzaidehyde-2-aminopyridine-N-thiohydrazone (L-3) and salicylaldehyde-2-aminopyrtidine-N-thiohydrazone (L-4)] have been synthesized. The thiohydrazides, thiodiamine and thiohydrazones can exist as thione-thiol tautomer and coordinate as a bidentate N-S ligand. The ligands found to act in monobasic bidentate fashion. Analytical data reveals that metal to ligand stoichiometry is 1:2. The complexes have been characterized by elemental analysis, IR, mass, electronic and H-1 NMR spectroscopic studies. In vitro antibacterial and cytotoxic study have also been carried out for some complexes. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2006.04.038
• 作为产物：
  描述：

  2-氨基吡啶 在 氢氧化钾 作用下， 以 甲醇 、 水 为溶剂， 反应 1.75h， 生成 (2-aminopyridine-N-thio)-1,3-propanediamine
  参考文献：
  名称：

  Platinum (IV) thiohydrazide, thiodiamine and thiohydrazone complexes: A spectral, antibacterial and cytotoxic study

  摘要：

  Some platinum (IV) complexes [Pt(L)(2)Cl-2] [where, L = 2-aminopyridine-N-thiohydrazide (L-1), (2-aminopyridine-N-thio)-1,3-propanediamine (L-2), benzaidehyde-2-aminopyridine-N-thiohydrazone (L-3) and salicylaldehyde-2-aminopyrtidine-N-thiohydrazone (L-4)] have been synthesized. The thiohydrazides, thiodiamine and thiohydrazones can exist as thione-thiol tautomer and coordinate as a bidentate N-S ligand. The ligands found to act in monobasic bidentate fashion. Analytical data reveals that metal to ligand stoichiometry is 1:2. The complexes have been characterized by elemental analysis, IR, mass, electronic and H-1 NMR spectroscopic studies. In vitro antibacterial and cytotoxic study have also been carried out for some complexes. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2006.04.038

文献信息

• Thermal and spectral studies of palladium(II) complexes
  作者：A. K. Mishra、S. B. Mishra、N. Manav、N. K. Kaushik

  DOI：10.1007/s10973-006-7608-0

  日期：2007.11

  Palladium(II) complexes of type [Pd(L)Cl2] [where L =2-aminopyridine-N-thiohydrazide (L1), (2-aminopyridine-N-thio)-1,3-propanediamine (L2), benzaldehyde 2-aminopyridine-N-thiohydrazone (L3) and salicylaldehyde-2-aminopyridine-N-thiohydrazone (L4)] have been synthesized. The thiohydrazide, thiodiamine and thiohydrazones can exist as thione-thiol tautomer and coordinate as a bidentate N-S ligand. The

  [Pd（L）Cl 2类型]的钯（II）配合物[其中 L = 2-氨基吡啶-N-硫代酰肼（L 1），（2-氨基吡啶-N-硫代）-1,3-丙二胺（L 2）合成了苯甲醛2-氨基吡啶-N-硫hydr（L 3）和水杨醛-2-氨基吡啶-N-硫hydr（L 4）]。硫代肼，硫代二胺和硫代azo可作为硫酮-硫醇互变异构体存在，并作为二齿NS配体配位。发现该配体以双齿方式起作用。