2-((3-chlorophenyl)sulfonamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid | 1372985-48-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((3-chlorophenyl)sulfonamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
• 英文别名: 2-(3-chlorobenzenesulphonylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid；2-[(3-Chlorophenyl)sulfonylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid
• CAS: 1372985-48-2
• 化学式: C₁₅H₁₄ClNO₄S₂
• 分子量: 371.865
• InChiKey: SGVMSPZSPWTLLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以66.3 %的产率得到2-((3-chlorophenyl)sulfonamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
  参考文献：
  名称：

  Discovery of novel tetrahydrobenzothiophene derivatives as MSBA inhibitors for antimicrobial agents

  摘要：

  DOI：

  10.1016/j.bioorg.2023.106932

文献信息

• Sulphonamine Compounds and Methods of Making and Using Same
  申请人：Zahler Robert

  公开号：US20130217759A1

  公开（公告）日：2013-08-22

  The invention provides sulphonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various sulphone compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

  本发明提供了磺酰胺类化合物及其在治疗医学障碍（如肥胖症）中的应用。提供了制备各种磺酮化合物的药物组合物和方法。这些化合物被认为具有对甲硫氨酰氨肽酶2的活性。
• SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME
  申请人：Zafgen, Inc.

  公开号：EP2627632A1

  公开（公告）日：2013-08-21
• US9221787B2
  申请人：——

  公开号：US9221787B2

  公开（公告）日：2015-12-29
• [EN] SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME<br/>[FR] COMPOSÉS SULFONAMIDES ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：ZAFGEN CORP

  公开号：WO2012051318A1

  公开（公告）日：2012-04-19

  The invention provides sulphonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various sulphone compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.