4-(6-cyclohexyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)-N,N,3-trimethylbenzenesulfonamide | 1443750-37-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(6-cyclohexyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)-N,N,3-trimethylbenzenesulfonamide
• CAS: 1443750-37-5
• 化学式: C₂₁H₂₆N₄O₂S
• 分子量: 398.529
• InChiKey: DUHHCGVHZUNAGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  87.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-bromo-6-cyclohexyl-5H-pyrrolo[2,3-b]pyrazine 、 4-(N,N-二甲基磺酰基)-2-甲基苯硼酸 以to give 60 mg as a white solid的产率得到4-(6-cyclohexyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)-N,N,3-trimethylbenzenesulfonamide
  参考文献：
  名称：

  DIAZAINDOLE INHIBITORS OF CRAC

  摘要：

  本发明涉及一种公式（I）的化合物，其通过调节钙释放激活的钙（CRAC）通道，用于治疗与IL-2抑制相关的自身免疫和炎症性疾病。还公开了制备和使用这些化合物治疗与CRAC通道相关的疾病的方法。

  公开号：

  US20130158040A1

文献信息

• NOVEL EFFECTIVE ANTIVIRAL COMPOUNDS AND METHODS USING SAME
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US20170114060A1

  公开（公告）日：2017-04-27

  The present invention includes compounds that are useful in preventing or treating viral infections caused by an enveloped RNA virus, such as viral infections caused by a Filovirus, arenavirus, rhabdovirus, paramyxovirus, orthomyxovirus and/or retrovirus. The present invention further includes compositions comprising such compounds, and methods of treating a viral infection in a subject using such compounds.
• [EN] DIAZAINDOLE INHIBITORS OF CRAC<br/>[FR] INHIBITEURS DIAZAINDOLE DU CRAC
  申请人：HOFFMANN LA ROCHE

  公开号：WO2013092444A1

  公开（公告）日：2013-06-27

  Disclosed are compounds of Formula (I): Formula (I), useful for treatment of autoimmune and inflammatory diseases associated with IL-2 inhibition via modulation of calcium release-activated calcium (CRAC) channels. Also disclosed are methods of making and using the compounds for treatment of diseases associated with CRAC channels.
• [EN] NOVEL EFFECTIVE ANTIVIRAL COMPOUNDS AND METHODS USING SAME<br/>[FR] NOUVEAUX COMPOSÉS ANTIVIRAUX EFFICACES ET LEURS MÉTHODES D'UTILISATION
  申请人：UNIV PENNSYLVANIA

  公开号：WO2015187827A1

  公开（公告）日：2015-12-10

  The present invention includes compounds that are useful in preventing or treating viral infections caused by an enveloped RNA virus, such as viral infections caused by a filovirus, arenavirus, rhabdovirus, paramyxovirus, orthomyxovirus and/or retrovirus. The present invention further includes compositions comprising such compounds, and methods of treating a viral infection in a subject using such compounds.
• [EN] METHODS AND COMPOSITIONS FOR TREATING ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR TRAITER UNE LÉSION PULMONAIRE AIGUË ET UN SYNDROME DE DÉTRESSE RESPIRATOIRE AIGUË
  申请人：CALCIMEDICA INC

  公开号：WO2021189013A1

  公开（公告）日：2021-09-23

  Compositions and methods related to the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) including viral pneumonia through the pharmaceutical manipulation of calcium signaling are disclosed. Such compositions and methods may be used to reduce pro-inflammatory cytokine releases that may lead to ALI and/or ARDS.