1-{[1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4,5-dimethyl-2-(3'-methyl-4-biphenylyl)-1H-imidazole | 1366767-05-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-{[1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4,5-dimethyl-2-(3'-methyl-4-biphenylyl)-1H-imidazole
• 英文别名: Cyclopropyl-[3-[[4,5-dimethyl-2-[4-(3-methylphenyl)phenyl]imidazol-1-yl]methyl]pyrrolidin-1-yl]methanone
• CAS: 1366767-05-6
• 化学式: C₂₇H₃₁N₃O
• 分子量: 413.563
• InChiKey: USOKMCDBJXLLNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  38.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] FATTY ACID SYNTHASE INHIBITORS<br/>[FR] INHIBITEURS DE L'ACIDE GRAS SYNTHASE
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2012037298A1

  公开（公告）日：2012-03-22

  This invention relates to the use of imidazole, triazole, and tetrazole derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of imidazoles, triazoles, and tetrazoles in the treatment of cancer.

  这项发明涉及使用咪唑、三唑和四唑衍生物来调节，尤其是抑制脂肪酸合酶（FAS）的活性或功能。适当地，本发明涉及在癌症治疗中使用咪唑、三唑和四唑。
• [EN] METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS<br/>[FR] MÉTHODES DE TRAITEMENT DE TROUBLES NEUROLOGIQUES
  申请人：YUMANITY THERAPEUTICS INC

  公开号：WO2020150423A1

  公开（公告）日：2020-07-23

  The present disclosure provides compounds and methods useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

  本公开提供了在治疗神经系统疾病中有用的化合物和方法。本发明的化合物可以单独或与其他药用活性剂结合使用，用于治疗或预防神经系统疾病。
• FATTY ACID SYNTHASE INHIBITORS
  申请人：Aquino Christopher Joseph

  公开号：US20130196971A1

  公开（公告）日：2013-08-01

  This invention relates to the use of imidazole, triazole, and tetrazole derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of imidazoles, triazoles, and tetrazoles in the treatment of cancer.

  本发明涉及使用咪唑，三唑和四唑衍生物来调节，特别是抑制脂肪酸合酶（FAS）的活性或功能。适当地，本发明涉及在癌症治疗中使用咪唑，三唑和四唑。
• METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：Yumanity Therapeutics, Inc.

  公开号：US20200222400A1

  公开（公告）日：2020-07-16

  The present disclosure provides compounds and methods useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.