The present invention relates to 1-aryl-3-aniline-5-alkyl-1,2,4-triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I).
The invention particularly relates to potent positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
本发明涉及1-芳基-3-
苯胺-5-烷基-
1,2,4-三唑衍
生物及其类似物或药学上可接受的盐,制备它们的过程,包含它们的制药组合物以及它们在治疗中的用途,根据式(I)。本发明特别涉及正向变构调节
尼古丁乙酰胆碱受体的强效物质,这种正向变构调节剂具有增加
尼古丁受体激动剂效力的能力。