5-[4-({16-[6-(3-carboxy-4-fluorophenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl]-16-oxo-3,6,9,12-tetraoxa-15-azahexadec-1-yl}carbamoyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoic acid | 1446176-44-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-[4-({16-[6-(3-carboxy-4-fluorophenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl]-16-oxo-3,6,9,12-tetraoxa-15-azahexadec-1-yl}carbamoyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoic acid
• 英文别名: 5-[4-[2-[2-[2-[2-[2-[[6-(3-carboxy-4-fluorophenyl)-3-phenyl-2H-pyrazolo[3,4-b]pyridine-4-carbonyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethylcarbamoyl]-3-phenyl-2H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoic acid
• CAS: 1446176-44-8
• 化学式: C₅₀H₄₄F₂N₈O₁₀
• 分子量: 954.944
• InChiKey: YPFIEFINFLROIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  70
• 可旋转键数：
  23
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  253
• 氢给体数：
  6
• 氢受体数：
  16

文献信息

• [EN] FGF RECEPTOR (FGFR) AGONIST DIMERIC COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND THERAPEUTIC USE THEREOF<br/>[FR] COMPOSÉS DIMÈRES AGONISTES DU RÉCEPTEUR DU FGF (FGFR), PROCÉDÉ D'ÉLABORATION, ET UTILISATION THÉRAPEUTIQUE DE CES COMPOSÉS
  申请人：SANOFI SA

  公开号：WO2013098764A1

  公开（公告）日：2013-07-04

  The invention relates to novel heterocyclic compounds which are pyrazolopyridine derivatives that induce fibroblast growth factor receptor (FGFR) dimerization, having the general formula: M1-L-M2 in which M1 or M2, which may be identical or different, each represent, independently of one another, a monomer unit M and L represents a linker group which links M1 and M2 covalently with the monomer unit which follows: Process for the preparation thereof and therapeutic use thereof.

  这项发明涉及新型杂环化合物，为嘧啶吡啶衍生物，能诱导成纤维细胞生长因子受体（FGFR）二聚化，其一般式为：M1-L-M2，其中M1或M2，可以相同也可以不同，各自独立地代表单体单元M，L代表将M1和M2以共价键连接的连接基团，随后的单体单元为：其制备方法和治疗用途。
• FGF Receptor (FGFR) Agonist Dimeric Compounds, Process for the Preparation Thereof and Therapeutic Use Thereof
  申请人：Sanofi

  公开号：US20150011579A1

  公开（公告）日：2015-01-08

  The invention relates to novel heterocyclic compounds which are pyrazolopyridine derivatives that induce fibroblast growth factor receptor (FGFR) dimerization, having the general formula: M 1 -L-M 2 in which M 1 or M 2 , which may be identical or different, each represent, independently of one another, a monomer unit M and L represents a linker group which links M 1 and M 2 covalently with the monomer unit which follows: Process for the preparation thereof and therapeutic use thereof.

  本发明涉及一种新型杂环化合物，它是吡唑吡啶衍生物，能引起成纤维细胞生长因子受体（FGFR）二聚化，其一般式为：M1-L-M2，其中M1或M2，可以相同也可以不同，分别独立地表示单体单位M，L表示连接M1和M2与其后面的单体单位的连接基：其制备方法和治疗用途。
• FGF RECEPTOR (FGFR) AGONIST DIMERIC COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
  申请人：SANOFI

  公开号：EP2797917A1

  公开（公告）日：2014-11-05
• US9034898B2
  申请人：——

  公开号：US9034898B2

  公开（公告）日：2015-05-19
• US9268063B2
  申请人：——

  公开号：US9268063B2

  公开（公告）日：2016-02-23