| 144002-83-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• CAS: 144002-83-5
• 化学式: C₄₁H₅₁N₂O₈P
• 分子量: 730.838
• InChiKey: CWJASMOLTHPSQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.69
• 重原子数：
  52.0
• 可旋转键数：
  23.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  132.42
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  N'-<6-(tert-butyldimethylsiloxy)hexyl>-N-<(6-(4,4'-dimethoxytrityl)oxy)hexyl>terephthalamide 在 咪唑 、 四丁基氟化铵 、 水 、 三乙胺 、 三氯化磷 作用下， 以 四氢呋喃 为溶剂， 反应 7.5h， 生成
  参考文献：
  名称：

  Control of folding and binding of oligonucleotides by use of a nonnucleotide linker

  摘要：

  A linker containing a terephthalamide group, -P(O)(O-)O(CH2)6NHC(O)C6H4C(O)NH(CH2)6OP(O)(O-)-, is shown to be an effective structural element for organizing oligonucleotide chains in solution. Capping a pair of complementary oligonucleotides with this linker leads to marked enhancement in stability of the Watson-Crick duplex structure. Joining a pair of thymidylate oligomers with this linker gives a compound exhibiting unusually high affinity for oligo(dA) strands; even a tetramer unit can be recognized in dilute solution. Presumably Hoogsteen as well as Watson-Crick hydrogen bonding stabilizes a bimolecular 'triplex". Both types of linkage (i.e., joining two complementary strands and joining two pyrimidine strands) are embodied in the novel compound, d(TTTTTT-X-TTTTTT-X-AAAAAA), and function jointly in stabilizing a doubly folded monomolecular triple stranded structure (T(m) 58-degrees-C, 1 M NaCl; -X- represents the terephthalamide linker group).

  DOI：

  10.1021/ja00049a003