N2,N2,6-trimethyl-7-phenyl-1,8-naphthyridine-2,4-diamine | 1179316-73-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N2,N2,6-trimethyl-7-phenyl-1,8-naphthyridine-2,4-diamine
• 英文别名: 2-N,2-N,6-trimethyl-7-phenyl-1,8-naphthyridine-2,4-diamine
• CAS: 1179316-73-4
• 化学式: C₁₇H₁₈N₄
• 分子量: 278.357
• InChiKey: PZMGATJTRKPULL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N'-(3-cyano-5-methyl-6-phenylpyridin-2-yl)-N,N-dimethylethanimidamide 在 sodium amide 作用下， 以 甲苯 为溶剂， 反应 10.0h， 以95%的产率得到N2,N2,6-trimethyl-7-phenyl-1,8-naphthyridine-2,4-diamine
  参考文献：
  名称：

  Synthesis and cytotoxic activity of 5,6-heteroaromatically annulated pyridine-2,4-diamines

  摘要：

  A series of 5,6-heteroaromatically annulated pyridine-2,4-diamines have been synthesized and their in vitro cytotoxic activities evaluated against six human cancer cell lines. Benzo[g] annulated pyrido[2,3-b]indolediamines 7a-b and 8 showed relatively high cytotoxic activity as well as most of the diamines with pyrrolo[2,3-b] pyridine 17, thieno[2,3-b] pyridine and furo[2,3-b] pyridine 26-28, 1,8-naphthyridine 32 and 34 and benzo[h] quinoline 37 skeletons. Surprisingly, pyrido[2,3-b] indolediamines 13 and 14 without benzo[g] annulation were inactive. None of the new compounds were as potent as ellipticine, the reference compound. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.05.016