3,3-diphenyl-N-(2-piperidin-1-yl-ethyl)-propionamide | 130234-26-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3-diphenyl-N-(2-piperidin-1-yl-ethyl)-propionamide
• 英文别名: N-2-(1-piperidino-)-ethyl-3,3-diphenylpropionamide；3,3-diphenyl-N-(2-piperidin-1-ylethyl)propanamide
• CAS: 130234-26-3
• 化学式: C₂₂H₂₈N₂O
• 分子量: 336.477
• InChiKey: LEDVFEWXGDXTIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Urea Derivatives Methods For Their Manufacture And Uses Thereof
  申请人：DePrez Pierre

  公开号：US20100240889A1

  公开（公告）日：2010-09-23

  The present invention provides compounds of formula (I): in which R 1 , R′ 1 , R 2 , R′ 2 , R 3 , Y and G have the meanings given in the description, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

  本发明提供了式（I）的化合物：其中R1，R′1，R2，R′2，R3，Y和G具有描述中给出的含义，以及它们的制备过程，它们通过药物的方式应用，以及含有它们的制药组合物。
• UREA DERIVATIVES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR
  申请人：DEPREZ Pierre

  公开号：US20120283255A1

  公开（公告）日：2012-11-08

  The present invention provides compounds of formula (I): in which R 1 , R′ 1 , R 2 , R′ 2 , R 3 , and Y have the meanings given in the description, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

  本发明提供了公式（I）的化合物：其中R1，R′1，R2，R′2，R3和Y具有描述中给出的含义，以及它们的制备方法，通过药物的方式应用它们，以及包含它们的制药组合物。
• Compounds for the treatment of urinary incontinence
  申请人：Kabi Pharmacia AB

  公开号：EP0367040A1

  公开（公告）日：1990-05-09

  The invention concerns compounds having the formula I wherein Ar is a phenyl or benzyl group which is optionally substituted with hydroxy or alkoxy; R¹ is hydrogen, lower alkyl, lower alkoxy, hydroxy; R² is hydrogen, lower alkyl; R³ is NR⁴R⁵, wherein R⁴ and R⁵ which can be the same or different, are lower al­kyl, or wherein R⁴ and R⁵, when taken together, form a ring with the nitrogen atom, whereby said ring optionally is sub­stituted with lower alkyl; n is 0 or 1; m is 2 or 3 and their salts with physiologically acceptable acids and when the compounds can be in form of optical isomers, the racemic mixture and the individual isomers, for the treatment of dis­orders of the urinary bladder.

  本发明涉及具有式 I 的化合物 其中 Ar 是苯基或苄基，可选择被羟基或烷氧基取代； R¹ 是氢、低级烷基、低级烷氧基、羟基； R² 是氢、低级烷基 R³ 是 NR⁴R⁵，其中 R⁴ 和 R⁵ 可以相同或不同，均为低级烷基，或其中 R⁴ 和 R⁵ 合在一起时与氮原子形成一个环，其中所述环可选择被低级烷基取代； n 为 0 或 1； m 为 2 或 3，以及 它们与生理上可接受的酸的盐，以及当化合物可以光学异构体、外消旋混合物和单个异构体的形式存在时，用于治疗膀胱疾病。
• Urea derivatives, methods for their manufacture, and uses thereof
  申请人：Galapagos SAS

  公开号：EP2354137A1

  公开（公告）日：2011-08-10

  The present invention provides compounds of formula (I): in which R1, R'1, R2, R'2, R3, Y and G have the meanings given in the description, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

  本发明提供了式 (I) 的化合物： 中 R1、R'1、R2、R'2、R3、Y 和 G 的含义，以及它们的制备工艺、它们在药物中的应用和含有它们的药物组合物。
• UREA DERIVATIVES METHODS FOR THEIR MANUFACTURE AND USES THEREOF
  申请人：Proskelia SAS

  公开号：EP1874765A2

  公开（公告）日：2008-01-09