Methyl 3-[6-(4-chlorophenylsulfonyl)amino-2-(2-tosyloxyethyl)-5,6,7,8tetrahydronaphth-1-yl]propanoate | 213314-00-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 3-[6-(4-chlorophenylsulfonyl)amino-2-(2-tosyloxyethyl)-5,6,7,8tetrahydronaphth-1-yl]propanoate
• 英文别名: Methyl 3-[6-[(4-chlorophenyl)sulfonylamino]-2-[2-(4-methylphenyl)sulfonyloxyethyl]-5,6,7,8-tetrahydronaphthalen-1-yl]propanoate
• CAS: 213314-00-2
• 化学式: C₂₉H₃₂ClNO₇S₂
• 分子量: 606.161
• InChiKey: PAFHRVBAEAQANP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  40
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  133
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• New benzenesulfonamide compounds
  申请人：——

  公开号：US20010009915A1

  公开（公告）日：2001-07-26

  Compound of formula (I): 1 wherein: n is from 1 to 3, and m is from 0 to 6, R a represents hydroxy, alkoxy, aryloxy or arylalkyloxy, R 1 and R 2 represent independently hydrogen, halogen, alkyl, alkoxy, hydroxy or perhaloalkyl, R 3 represents hydrogen, or alkyl, arylalkyl, cycloalkylalkyl, aryl or cycloalkyl, T 1 represents alkylene, O-alkylene, alkylene-O— or (C 1 -C 3 )alkylene-O— (C 1 -C 3 )alkylene, G represents G 1 - or G 1 -T 2 -A-, wherein: A represents aryl, T 2 represents a bond or alkylene, —O-alkylene, alkylene—O— or (C 1 -C 3 )-alkylene-O—(C 1 -C 3 )alkylene, G 1 represents —NR 4 R 5 , or G 1 represents heterocycloalkyl a formula 2 having from 5 to 7 ring members wherein Y represents a nitrogen atom, oxygen or CH and R 4 , R 5 and R 6 are as defined in the description, and medicinal products containing the same are useful as TXA 2 receptor antagonist and 5-HT 2 receptor antagonist.

  化合物的公式（I）：其中：n为1至3，m为0至6，R代表羟基，烷氧基，芳氧基或芳基烷氧基，R1和R2独立地代表氢，卤素，烷基，烷氧基，羟基或全氟烷基，R3代表氢，或烷基，芳基烷基，环烷基烷基，芳基或环烷基，T1代表烷基，O-烷基，烷基-O-或（C1-C3）烷基-O-（C1-C3）烷基，G代表G1-或G1-T2-A-，其中：A代表芳基，T2代表键或烷基，-O-烷基，烷基-O-或（C1-C3）-烷基-O-（C1-C3）烷基，G1代表-NR4R5或G1代表具有5至7个环成员的杂环烷基式2，其中Y代表氮原子，氧或CH，R4，R5和R6如描述中所定义，以及含有它们的药物作为TXA2受体拮抗剂和5-HT2受体拮抗剂是有用的。
• Benzenesulfonamide compounds
  申请人：——

  公开号：US20020137742A1

  公开（公告）日：2002-09-26

  Compound of formula (I): 1 wherein n is from 1 to 3, and m is from 0 to 6, R a represents hydroxy, alkoxy, aryloxy or arylalkyloxy, R 1 and R 2 represent independently hydrogen, halogen, alkyl, alkoxy, hydroxy or perhaloalkyl, R 3 represents hydrogen, or alkyl, arylalkyl, cycloalkylalkyl, aryl or cycloalkyl, T 1 represents alkylene, O-alkylene, alkylene-O- or (C 1 -C 3 )alkylene-O-(C 1 -C 3 )alkylene, G represents G 1 - or G 1 -T 2 -A-, wherein: A represents aryl, T 2 represents a bond or alkylene, —O-alkylene, alkylene-O- or (C 1 -C 3 )-alkylene-O- (C 1 -C 3 )alkylene, G 1 represents-NR 4 R 5 , or G 1 represents heterocycloalkyl a formula 2 having from 5 to 7 ring members wherein Y represents a nitrogen atom, oxygen or CH and R 4 , R 5 and R 6 are as defined in the description, and medicinal products containing the same are useful as TXA 2 receptor antagonist and 5 -HT 2 receptor antagonist.

  化合物式(I)的复合物：其中n为1至3，m为0至6，R代表羟基、烷氧基、芳氧基或芳基烷氧基，R1和R2独立地代表氢、卤素、烷基、烷氧基、羟基或全卤烷基，R3代表氢、或烷基、芳基烷基、环烷基烷基、芳基或环烷基，T1代表烷基、O-烷基、烷基-O-或（C1-C3）烷基-O-（C1-C3）烷基，G代表G1-或G1-T2-A-，其中：A代表芳基，T2代表键或烷基、-O-烷基、烷基-O-或（C1-C3）-烷基-O-（C1-C3）烷基，G1代表-NR4R5，或G1代表具有5至7个环成员的杂环烷基式2，其中Y代表氮原子、氧或CH，R4、R5和R6如描述中所定义，以及含有该化合物的药物可用作TXA2受体拮抗剂和5-HT2受体拮抗剂。
• US6013667A
  申请人：——

  公开号：US6013667A

  公开（公告）日：2000-01-11
• US6469011B2
  申请人：——

  公开号：US6469011B2

  公开（公告）日：2002-10-22
• US6545037B2
  申请人：——

  公开号：US6545037B2

  公开（公告）日：2003-04-08