2,5-Dimethyl-4-(propan-2-yl)aniline | 63316-82-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,5-Dimethyl-4-(propan-2-yl)aniline
• 英文别名: 2,5-dimethyl-4-propan-2-ylaniline
• CAS: 63316-82-5
• 化学式: C₁₁H₁₇N
• 分子量: 163.26
• InChiKey: AZDNQDHDPDHSBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• TRANSCRIPTIONALLY TARGETED AND CPG-FREE PLASMID FOR THERANOSTIC GENE THERAPY
  申请人：The Johns Hopkins University

  公开号：US20200140831A1

  公开（公告）日：2020-05-07

  A DNA plasmid useful for diagnostic and therapeutic gene therapy is disclosed. Improvements to gene therapy methods known in the art are provided to ensure cancer-targeting, high efficacy, and long durability of expression. The DNA plasmid is combined with compositions of polymeric nanoparticles for non-viral gene therapy to treat cancer, including hepatocellular carcinoma and prostate cancer.
• NONVIRAL GENE TRANSFER TO THE SUPRACHOROIDAL SPACE
  申请人：The Johns Hopkins University

  公开号：US20200330396A1

  公开（公告）日：2020-10-22

  The presently disclosed subject matter provides compositions and methods for administering a nanoparticle or microparticle and a therapeutic agent to the suprachoroidal space in the eye.
• GENE DELIVERY PARTICLES TO INDUCE TUMOR-DERIVED ANTIGEN PRESENTING CELLS
  申请人：The Johns Hopkins University

  公开号：US20220154219A1

  公开（公告）日：2022-05-19

  Synthetic, biodegradable nanoparticles (NPs) encapsulating at least one of a signal 1 protein, a signal 2 protein, and/or a signal 3 protein are disclosed, which, when transfected into one or more a cancer cells, reprogram the one or more cancer cells into “tumor-derived APCs” in vivo to activate T-cells and natural killer (NK) cells for systemic tumor rejection. The NPs can be used for treating cancers, in particular metastatic cancers.
• US9884118B2
  申请人：——

  公开号：US9884118B2

  公开（公告）日：2018-02-06